Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway

S.A.K. received support from National Institute of Mental Health-National Research Service Award Grant MH063541, National Institutes of Health (NIH)-National Institute of General Medical Sciences Grant GM08042, the Medical Scientist Training Program, the Aesculapians Fund of the University of California Los Angeles School of Medicine, and the Tennenbaum Family Creativity Initiative. Y.E. was supported by grants from Nederlandse Organisatie voor Wetenschappelijk Onderzoek-Zorgonderzoek Nederland Medische Wetenschappen (VIDI and TOP). This work was also supported by a generous donation from C. M. Spivak and by grants from the Michael Tennenbaum Creativity Initiative, NIH (Grant R01 NS038480), Neurofibromatosis (National, Illinois, Massachusetts Bay Area, Minnesota, Arizona, Kansas and Central Plains, Mid-Atlantic, and Texas chapters), and the Merck and Neuroscience Nursing Foundations (A.J.S.). We thank L. van Aelst for the human H-ras^G12V cDNA, M. Mayford for the pMM403 plasmids, and P. Greengard and J. N. Jovanovic for the phospho-SynI antibodies. We also thank M. Elgersma for help with in situ hybridization and immunohistochemistry. We are grateful to J. G. Borst, D. V. Buonomano, P. W. Frankland, S. A. Josselyn, J. N. Jovanovic, K. C. Martin, T. J. O'Dell, and F. E. Schweizer for fruitful discussions.

Correspondence should be addressed to Alcino Silva, Departments of Neurobiology, Psychiatry, and Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095-1761. E-mail: silvaa{at}mednet.ucla.edu.

Copyright © 2005 Society for Neuroscience 0270-6474/05/259721-14$15.00/0

↵* S.A.K. and Y.E. contributed equally to this work.