In the article “Highly Efficient Small Interfering RNA Delivery to Primary Mammalian Neurons Induces MicroRNA-Like Effects before mRNA Degradation,” by Thomas J. Davidson, Sivan Harel, Valerie A. Arboleda, Giselle F. Prunell, Michael L. Shelanski, Lloyd A. Greene, and Carol M. Troy, which appeared on pages 10040-10046 of the November 10, 2004 issue, S-S-Pen1 as shown in Figure 1 is on the wrong side of the sense strand (i.e., shown on the 3′ end when it should be on the 5′ end). This figure also shows an error in the accession number for SOD1 and a typographical error in the Casp8 sequence. A revised version of Figure 1, with these errors corrected, is printed here.
Scheme showing sequences and mRNA target sites of V-siRNAs. All V-siRNAs have perfect homology (black rectangles) to sites within the open reading frame (region between open triangles) of targeted mRNA. National Center for Biotechnology Information accession numbers are provided for rat mRNA. Both sense (gray; 5′ to 3′) and antisense (black; 3′ to 5′) sequences of V-siRNAs used are shown.
