Few Ca_V1.3 Channels Regulate the Exocytosis of a Synaptic Vesicle at the Hair Cell Ribbon Synapse

This work was supported by a Deutsche Forschungsgemeinschaft grant (SFB 406), a Human Frontier Science Program grant to T.M., and a Bundesministerium fuer Bildung und Forschung grant to F. Wolf and T.M. (through the Bernstein Center for Computational Neuroscience, Goettingen, Germany). The experimental work was performed by A.B. (electrophysiology) and D.K. (immunohistochemistry). We thank J. Striessnig for providing Ca_V1.3 knock-out mice. We also thank F. Wolf for ongoing help and discussion; C. Meinrenken, R. W. Tsien, P. Pirih, and A. Neef for suggestions and discussion; and R. Schneggenburger, F. Wolf, A. Neef, T. Sakaba, and C. Arglebe for their comments on this manuscript. We thank Margitta Köppler for excellent technical assistance.

Correspondence should be addressed to Tobias Moser, Department of Otolaryngology, University of Goettingen, 37099 Goettingen, Germany. E-mail: tmoser{at}gwdg.de.

DOI:10.1523/JNEUROSCI.3411-05.2005

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