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Cellular/Molecular

Trafficking of a Ligand-Receptor Complex on the Growth Cones as an Essential Step for the Uptake of Nerve Growth Factor at the Distal End of the Axon: A Single-Molecule Analysis

Tomomi Tani, Yoshikazu Miyamoto, Kazuhiro E. Fujimori, Takahisa Taguchi, Toshio Yanagida, Yasushi Sako and Yoshie Harada
Journal of Neuroscience 2 March 2005, 25 (9) 2181-2191; DOI: https://doi.org/10.1523/JNEUROSCI.4570-04.2005
Tomomi Tani
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Yoshikazu Miyamoto
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Kazuhiro E. Fujimori
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Takahisa Taguchi
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Toshio Yanagida
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Yasushi Sako
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Yoshie Harada
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4570-04.2005
PubMed 
15745944
Published By 
Society for Neuroscience
History 
  • Received November 7, 2004
  • Revision received January 5, 2005
  • Accepted January 6, 2005
  • First published March 2, 2005.
  • Version of record published March 2, 2005.
Copyright & Usage 
Copyright © 2005 Society for Neuroscience 0270-6474/05/252181-11.00/0

Author Information

  1. Tomomi Tani1,
  2. Yoshikazu Miyamoto2,
  3. Kazuhiro E. Fujimori3,
  4. Takahisa Taguchi3,
  5. Toshio Yanagida2,5,
  6. Yasushi Sako2,4, and
  7. Yoshie Harada1,5
  1. 1Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan, 2Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan, 3Cell Engineering Research Institute, Advanced Industrial Science and Technology, Ikeda 563-8577, Japan, and 4Precursory Research for Embryonic Science and Technology, and 5Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan
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Author contributions

Disclosures

    • Received November 7, 2004.
    • Revision received January 5, 2005.
    • Accepted January 6, 2005.
  • This work was supported by a grant-in-aid for Scientific Research from the Japan Society for the Promotion of Science and the Basic Research Programs of the Japan Science and Technology Agency. We thank Dr. Masahiro Ueda for his suggestion of introducing single molecule detection techniques for the study of the growth cone, Dr. Tetsuichi Wazawa for his advice on the synthesis of fluorescent conjugates, and Dr. Richard D. Allen for his critical reading of this manuscript.

  • Correspondence should be addressed to Tomomi Tani, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-ku, Tokyo 113-8613, Japan. E-mail: ttani{at}rinshoken.or.jp.

  • Copyright © 2005 Society for Neuroscience 0270-6474/05/252181-11$15.00/0

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Article usage: March 2005 to March 2021

AbstractFullPdf
Mar 2005764434621
Apr 20053410868
May 2005207561
Jun 2005286261
Jul 2005103717
Aug 2005164127
Sep 200576735
Oct 2005234520
Nov 2005153219
Dec 2005103820
Total 2005927939949
Jan 2006134522
Feb 2006115216
Mar 200653423
Apr 200634318
May 200662815
Jun 200673623
Jul 200642622
Aug 2006123326
Sep 2006103822
Oct 200664225
Nov 200673633
Dec 200653320
Total 200689446265
Jan 200752931
Feb 200733119
Mar 2007174224
Apr 200722823
May 200794935
Jun 200784540
Jul 200743534
Aug 2007183415
Sep 200782718
Oct 200782814
Nov 200752619
Dec 200791811
Total 200796392283
Jan 200861420
Feb 2008102216
Mar 2008101310
Apr 200891210
May 2008124026
Jun 200871312
Jul 200852119
Aug 2008162718
Sep 2008141519
Oct 2008112516
Nov 2008373210
Dec 2008142323
Total 2008151257199
Jan 20099137
Feb 200972419
Mar 2009171717
Apr 200981413
May 2009575
Jun 2009112210
Jul 200991919
Aug 20099154
Sep 200972210
Oct 200941319
Nov 2009987
Dec 2009131112
Total 2009108185142
Jan 201051011
Feb 2010141210
Mar 2010467
Apr 201071110
May 201031413
Jun 201021135
Jul 20106117
Aug 201024177
Sep 201028810
Oct 201071414
Nov 2010101718
Dec 2010121923
Total 2010141152135
Jan 201191416
Feb 2011101215
Mar 2011878
Apr 2011112517
May 201111109
Jun 201181515
Jul 201191614
Aug 201119714
Sep 201115118
Oct 2011182211
Nov 201116116
Dec 20111867
Total 2011152156140
Jan 2012141711
Feb 20121798
Mar 2012221110
Apr 2012211925
May 201218916
Jun 2012132215
Jul 201217212
Aug 2012131012
Sep 20121369
Oct 201213616
Nov 20122772
Dec 2012321516
Total 2012220133152
Jan 201320710
Feb 20131825
Mar 201329118
Apr 2013251511
May 2013201511
Jun 201313115
Jul 2013402325
Aug 2013573
Sep 2013141111
Oct 2013894
Nov 20132557
Dec 201326102
Total 2013243126102
Jan 20142797
Feb 201423616
Mar 20141858
Apr 201423159
May 2014182110
Jun 201420117
Jul 2014262911
Aug 2014189
Sep 2014654
Oct 20141948
Nov 2014768
Dec 20141384
Total 2014201127101
Jan 20159147
Feb 20152274
Mar 20151945
Apr 201517168
May 2015152010
Jun 201511124
Jul 2015475
Aug 20151273
Sep 201513106
Oct 2015251
Nov 20151551
Dec 20151750
Total 201515611254
Jan 20162488
Feb 201616104
Mar 2016231310
Apr 20161173
May 2016121210
Jun 20168154
Jul 2016855
Aug 20161272
Sep 20161373
Oct 2016871
Nov 2016467
Dec 201641411
Total 201614311168
Jan 201723316
Feb 2017363
Mar 20170106
Apr 2017083
May 20174187
Jun 2017154
Jul 20170163
Aug 20172103
Sep 2017170
Oct 20173123
Nov 20171855
Dec 2017460
Total 20172121653
Jan 20181112
Feb 2018192
Mar 20183118
Apr 2018390
May 20182112
Jun 20182193
Jul 20187143
Aug 201813103
Sep 20185305
Oct 20181155
Nov 2018192
Dec 2018171
Total 20184015536
Jan 2019243
Feb 2019173
Mar 20194116
Apr 2019554
May 2019244
Jun 2019143
Jul 2019532
Aug 20192453
Sep 20195303
Oct 20191575
Nov 2019395
Dec 20190105
Total 20193118946
Jan 20205161
Feb 20203132
Mar 2020182
Apr 2020041
May 2020282
Jun 2020225
Jul 2020021
Aug 2020084
Sep 20201163
Oct 20202176
Nov 20206176
Dec 20207164
Total 20202912737
Jan 20213136
Feb 20212107
Mar 2021043
Total 202152716
Total275338502778
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The Journal of Neuroscience: 25 (9)
Journal of Neuroscience
Vol. 25, Issue 9
2 Mar 2005
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Trafficking of a Ligand-Receptor Complex on the Growth Cones as an Essential Step for the Uptake of Nerve Growth Factor at the Distal End of the Axon: A Single-Molecule Analysis
Tomomi Tani, Yoshikazu Miyamoto, Kazuhiro E. Fujimori, Takahisa Taguchi, Toshio Yanagida, Yasushi Sako, Yoshie Harada
Journal of Neuroscience 2 March 2005, 25 (9) 2181-2191; DOI: 10.1523/JNEUROSCI.4570-04.2005

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Trafficking of a Ligand-Receptor Complex on the Growth Cones as an Essential Step for the Uptake of Nerve Growth Factor at the Distal End of the Axon: A Single-Molecule Analysis
Tomomi Tani, Yoshikazu Miyamoto, Kazuhiro E. Fujimori, Takahisa Taguchi, Toshio Yanagida, Yasushi Sako, Yoshie Harada
Journal of Neuroscience 2 March 2005, 25 (9) 2181-2191; DOI: 10.1523/JNEUROSCI.4570-04.2005
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