Figure 1.
Bar charts representing the mean levels of intracranial pressure measured 1 and 2 h before injury as well as 2, 3, 6, and 7 h after injury (black column, noninfused injured, n = 10; gray column, infused injured, 4 h survival, n = 10; white column, infused injured, 8 h survival, n = 11). No elevation in ICP was found in injected-non-injured sham animals, indicating that controlled infusion into the lateral ventricle does not increase ICP (data not shown). No significant difference in ICP was observed between injected-injured and non-injected-injured animals at 4 or 8 h after injury, indicating that infusion into the lateral ventricle does not complicate any ICP change associated with closed head injury. Note, however, that in this injury model, the traumatic episode was associated with a significant elevation of ICP. The ICP was elevated at each time point measured postinjury, particularly at 2, 3, 6, and 7 h after injury. Data are shown as mean ± SEM. The asterisk indicates statistical significance (p < 0.001).