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Articles, Behavioral/Systems/Cognitive

Amphetamine Exposure Enhances Habit Formation

Andrew Nelson and Simon Killcross
Journal of Neuroscience 5 April 2006, 26 (14) 3805-3812; DOI: https://doi.org/10.1523/JNEUROSCI.4305-05.2006
Andrew Nelson
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Simon Killcross
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    Figure 1.

    Effect of pretraining amphetamine sensitization on sensitivity of lever pressing (left) and magazine entry (right) to reward devaluation by specific satiety. Mean lever presses per minute and mean magazine entries per minute as a proportion of baseline (±SEM) in the extinction test after prefeeding with the instrumental outcome (white bars) or the alternative reinforcer (gray bars) are shown.

  • Figure 2.
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    Figure 2.

    Effect of pretraining amphetamine sensitization on sensitivity of lever pressing (left) and magazine entry (right) to reward devaluation by LiCl-induced nausea. Mean lever presses per minute and mean magazine entries per minutes as a proportion of baseline (±SEM) in the extinction test after devaluation by LiCl (white bars) or no devaluation (gray bars) are shown.

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    Figure 3.

    Effect of pretraining (left) and post-training (right) amphetamine sensitization on lever press reacquisition after reward devaluation by LiCl-induced nausea. Mean lever presses per minute (±SEM) in the rewarded reacquisition test after devaluation with LiCl (white bars) or no devaluation (gray bars) are shown.

  • Figure 4.
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    Figure 4.

    Effect of post-training amphetamine sensitization on sensitivity of lever pressing (left) and magazine entry (right) to reward devaluation by LiCl-induced nausea. Mean lever presses per minute and mean magazine entries per minute as a proportion of baseline (±SEM) in the extinction test after devaluation by LiCl (white bars) or no devaluation (gray bars) are shown.

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    Table 1.

    Key stages of training for experiments 1 and 2

    Stage 1Stage 2Stage 3Stage 4Stage 5
    Experiment 1Sensitization (days 1–14)Behavioral training (days 15–20)Specific satiety devaluation (days 21–22)LiCl devaluation and test (days 23–26)Reacquisition test (day 27)
    Experiment 2Behavioral training (days 1–6)Sensitization (days 7–20)LiCl devaluation and test (days 21–24)Reacquisition test (day 25)
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The Journal of Neuroscience: 26 (14)
Journal of Neuroscience
Vol. 26, Issue 14
5 Apr 2006
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Amphetamine Exposure Enhances Habit Formation
Andrew Nelson, Simon Killcross
Journal of Neuroscience 5 April 2006, 26 (14) 3805-3812; DOI: 10.1523/JNEUROSCI.4305-05.2006

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Amphetamine Exposure Enhances Habit Formation
Andrew Nelson, Simon Killcross
Journal of Neuroscience 5 April 2006, 26 (14) 3805-3812; DOI: 10.1523/JNEUROSCI.4305-05.2006
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