Requirement of Akt to Mediate Long-Term Synaptic Depression in Drosophila

LTD was primarily reduced in the akt mutant alleles akt⁴²²⁶ and akt⁴²²⁶/akt¹ (A) but not affected in the mutants of rutabaga, dunce, and latheo (B). A, Representative recordings (top) (calibration: 20 nA, 2 min) and summary of normalized EJC amplitude (bottom) in control and akt mutant alleles. WT, Wild type. B, Representative LTD recordings in the mutants of rutabaga (rut¹), dunce (dunce¹), and latheo (latheo^P1).