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Articles, Behavioral/Systems/Cognitive

The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology

Urs Meyer, Myriel Nyffeler, Andrea Engler, Adrian Urwyler, Manfred Schedlowski, Irene Knuesel, Benjamin K. Yee and Joram Feldon
Journal of Neuroscience 3 May 2006, 26 (18) 4752-4762; DOI: https://doi.org/10.1523/JNEUROSCI.0099-06.2006
Urs Meyer
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Myriel Nyffeler
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Andrea Engler
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Adrian Urwyler
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Manfred Schedlowski
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Irene Knuesel
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Benjamin K. Yee
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Joram Feldon
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Abstract

Disturbance to early brain development is implicated in several neuropsychiatric disorders including autism, schizophrenia, and mental retardation. Epidemiological studies have indicated that the risk of developing these disorders is enhanced by prenatal maternal infection, presumably as a result of neurodevelopmental defects triggered by cytokine-related inflammatory events. Here, we demonstrate that the effects of maternal immune challenge between middle and late gestation periods in mice are dissociable in terms of fetal brain cytokine responses to maternal inflammation and the pathological consequences in brain and behavior. Specifically, the relative expression of pro- and anti-inflammatory cytokines in the fetal brains in response to maternal immune challenge may be an important determinant among other developmental factors for the precise pathological profile emerging in later life. Thus, the middle and late gestation periods correspond to two windows with differing vulnerability to adult behavioral dysfunction, brain neuropathology in early adolescence, and of the acute cytokine responses in the fetal brain.

  • apoptosis
  • cytokines
  • inflammation
  • neurogenesis
  • prenatal
  • Reelin
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The Journal of Neuroscience: 26 (18)
Journal of Neuroscience
Vol. 26, Issue 18
3 May 2006
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The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology
Urs Meyer, Myriel Nyffeler, Andrea Engler, Adrian Urwyler, Manfred Schedlowski, Irene Knuesel, Benjamin K. Yee, Joram Feldon
Journal of Neuroscience 3 May 2006, 26 (18) 4752-4762; DOI: 10.1523/JNEUROSCI.0099-06.2006

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The Time of Prenatal Immune Challenge Determines the Specificity of Inflammation-Mediated Brain and Behavioral Pathology
Urs Meyer, Myriel Nyffeler, Andrea Engler, Adrian Urwyler, Manfred Schedlowski, Irene Knuesel, Benjamin K. Yee, Joram Feldon
Journal of Neuroscience 3 May 2006, 26 (18) 4752-4762; DOI: 10.1523/JNEUROSCI.0099-06.2006
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