Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
Articles, Behavioral/Systems/Cognitive

The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus

Anke Wallraff, Rüdiger Köhling, Uwe Heinemann, Martin Theis, Klaus Willecke and Christian Steinhäuser
Journal of Neuroscience 17 May 2006, 26 (20) 5438-5447; DOI: https://doi.org/10.1523/JNEUROSCI.0037-06.2006
Anke Wallraff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rüdiger Köhling
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Uwe Heinemann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Theis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Klaus Willecke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Steinhäuser
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site

Figure 5.

Figure 5.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 5.

Recovery of stimulation-induced increase of [K+]o in stratum pyramidale is slower in dko mice. A, Decline of representative, matched [K+]o transients after stimulus trains (20 Hz) evoked with high (wt, 100%; dko, 75%) and low (wt and dko, 50%) stimulus intensity. For the wt traces, t1/e (the time after which [K+]o amplitude has decayed to 1/e of its initial value) is indicated. Note that decay is faster for larger rises in [K+]o (dotted line, t1/e = 1.93 s; dashed line, t1/e = 2.35 s). B, t1/e values of [K+]o recovery after a stimulus train (20 Hz; 25, 50, 75, and 100% stimulation intensities) plotted against [K+]o at the end of the stimulus (wt, open diamonds; dko, filled squares). The inverse relationships between [K+]o and t1/e were best described by a power function (thin line for wt, y = 5.272x exp(−0.417); thick line for dko mice, y = 6.068x exp(−0.412). y-axis intercepts differed significantly (asterisk; see Results). C, Semilogarithmic plots of the decline of representative, matched [K+]o transients (from 90% to the trough of the undershoot; gray dots) after 100% stimulus trains (20 Hz). Top, wt; bottom, dko. Two exponential components contribute to this decline and are plotted individually (straight black lines; wt, τfast = 1.46 s, τslow = 11.3 s; dko, τfast = 1.15 s, τslow = 10.5 s). Their sum provides an excellent fit of the data (black curves). Note that the relative amplitude of τfast (τfast amplitude fraction) is larger in the wt (84%) compared with the dko [K+]o decay (70%). D, τfast amplitude fractions plotted against [K+]o at the end of the stimulus (wt, open diamonds; dko, filled squares). The linear relationship was significantly (asterisk) shifted toward smaller τfast amplitude fractions in dko mice (thin line, wt, linear equation: y = 0.0445x + 0.39; thick line, dko, y = 0.0346x + 0.38).

  View article

In this issue

The Journal of Neuroscience: 42 (21)
Journal of Neuroscience
Vol. 42, Issue 21
25 May 2022
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Figure 5.
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Figure 5.
Journal of Neuroscience Dec 1969,

Citation Manager Formats

Respond to this article
Request Permissions
Share
Figure 5.
Journal of Neuroscience Dec 1969,
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Related Articles

Cited By...

  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2022 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.