Article Figures & Data
Figures
- Figure 1.
Brain maps obtained with SPM showing the difference in the distribution volume of [11C]raclopride between the neutral and the cocaine-cue conditions (p < 0.05, uncorrected, threshold >100 voxels). Note that there were no differences in the ventral striatum (−8 canthomeatal plane).
- Figure 2.
A, Dopamine D2 receptor availability (Bmax/Kd) in caudate, putamen, and ventral striatum for the neutral and the cocaine-cue conditions. B, Craving measures (assessed with the CCQ) before (pre) and after (post) presentation of the neutral and the cocaine videos. C, Regression slopes for the correlation between changes in DA (percentage changes in Bmax/Kd from the neutral condition) and changes in cocaine craving (pre and post differences in CCQ scores). Values represent means ± SDs. Comparisons correspond to paired t tests (two-tailed) *p < 0.05; **p < 0.01.
Tables
Age 43 ± 6 years Gender 17 males, 1 female Ethnicity 15 African Americans, 3 caucasians Education 13 ± 2 years of education Years of cocaine use 15 ± 7 years Route of administration 18 smoked cocaine Dose used 2.8 ± 1.6 g/d Days since last cocaine use 2 ± 1.4 d (range,1 and 6 d) Cigarette smokers 15 current smokers - Table 2.
K1 (transport constant from plasma to tissue) and DV measures for the neutral and the cocaine-cue video conditions and t and p values for their comparisons (paired two-tail t test)
Neutral video Cocaine-cue video t p K 1 Cerebellum 0.12 ± 0.03 0.11 ± 0.04 0.33 0.75 Caudate 0.10 ± 0.01 0.11 ± 0.04 0.93 0.37 Putamen 0.11 ± 0.02 0.12 ± 0.04 1.00 0.33 Ventral striatum 0.10 ± 0.01 0.11 ± 0.03 0.60 0.55 DV Cerebellum 0.43 ± 0.06 0.43 ± 0.06 0.44 0.67 Caudate 1.44 ± 0.20 1.37 ± 0.24 2.02 0.06 Putamen 1.62 ± 0.22 1.53 ± 0.26 2.08 0.05 Ventral striatum 1.46 ± 0.26 1.42 ± 0.22 0.59 0.56 -
DV measures in putamen were significantly lower (p < 0.05) during the cocaine-cue condition and showed a trend in caudate (p < 0.06). None of the other measures differed. Values represent means ± SDs.
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