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Articles, Behavioral/Systems/Cognitive

Earlier Development of the Accumbens Relative to Orbitofrontal Cortex Might Underlie Risk-Taking Behavior in Adolescents

Adriana Galvan, Todd A. Hare, Cindy E. Parra, Jackie Penn, Henning Voss, Gary Glover and B. J. Casey
Journal of Neuroscience 21 June 2006, 26 (25) 6885-6892; https://doi.org/10.1523/JNEUROSCI.1062-06.2006
Adriana Galvan
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Todd A. Hare
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Cindy E. Parra
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Jackie Penn
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Henning Voss
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Gary Glover
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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B. J. Casey
1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1062-06.2006
PubMed 
16793895
Published By 
Society for Neuroscience
History 
  • Received January 5, 2006
  • Revision received May 15, 2006
  • Accepted May 25, 2006
  • First published June 21, 2006.
  • Version of record published June 21, 2006.
Copyright & Usage 
Copyright © 2006 Society for Neuroscience 0270-6474/06/266885-08$15.00/0

Author Information

  1. Adriana Galvan1,
  2. Todd A. Hare1,
  3. Cindy E. Parra1,
  4. Jackie Penn1,
  5. Henning Voss1,
  6. Gary Glover2, and
  7. B. J. Casey1
  1. 1The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, and 2Department of Radiology and Neurosciences Program, Center for Advanced Magnetic Resonance Technology at Stanford University, Stanford, California 94305
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Author contributions

Disclosures

    • Received January 5, 2006.
    • Revision received May 15, 2006.
    • Accepted May 25, 2006.
  • ↵a Cluster sizes of 6 and 10 for the accumbens and OFC, respectively, were determined by these simulations. Cluster sizes of 8 and 10 in the adolescent and child data, respectively, survived more stringent thresholds (p < 0.002 and p < 0.001, respectively). In the OFC, cluster sizes of 14 and 18 in adolescents and children, respectively, survived more stringent thresholds (p < 0.004 and p < 0.001, respectively).

  • This work was supported in part by National Institute on Drug Abuse Grants R01 DA18879 and R21 DA15882, National Institute of Mental Health Grant P50 MH62196 (B.J.C.), and National Eye Institute Grant T32 EY07138 fellowship (A.G.). We gratefully acknowledge all of the participants and their families for participating in this study and three anonymous reviewers.

  • Correspondence should be addressed to either Adriana Galvan or B. J. Casey, 1300 York Avenue, Box 140, New York, NY 10021. Email: adg2006{at}med.cornell.edu or bjc2002{at}med.cornell.edu

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The Journal of Neuroscience: 26 (25)
Journal of Neuroscience
Vol. 26, Issue 25
21 Jun 2006
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Earlier Development of the Accumbens Relative to Orbitofrontal Cortex Might Underlie Risk-Taking Behavior in Adolescents
Adriana Galvan, Todd A. Hare, Cindy E. Parra, Jackie Penn, Henning Voss, Gary Glover, B. J. Casey
Journal of Neuroscience 21 June 2006, 26 (25) 6885-6892; DOI: 10.1523/JNEUROSCI.1062-06.2006

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Earlier Development of the Accumbens Relative to Orbitofrontal Cortex Might Underlie Risk-Taking Behavior in Adolescents
Adriana Galvan, Todd A. Hare, Cindy E. Parra, Jackie Penn, Henning Voss, Gary Glover, B. J. Casey
Journal of Neuroscience 21 June 2006, 26 (25) 6885-6892; DOI: 10.1523/JNEUROSCI.1062-06.2006
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Keywords

  • accumbens
  • adolescent
  • reward
  • development
  • orbital frontal cortex
  • risk-taking

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