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Featured ArticleArticles, Development/Plasticity/Repair

Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy

Yo Sasaki, Toshiyuki Araki and Jeffrey Milbrandt
Journal of Neuroscience 16 August 2006, 26 (33) 8484-8491; https://doi.org/10.1523/JNEUROSCI.2320-06.2006
Yo Sasaki
1Departments of Pathology and Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, and 2Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
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Toshiyuki Araki
1Departments of Pathology and Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, and 2Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
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Jeffrey Milbrandt
1Departments of Pathology and Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, and 2Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2320-06.2006
PubMed 
16914673
Published By 
Society for Neuroscience
History 
  • Received June 1, 2006
  • Revision received June 27, 2006
  • Accepted July 3, 2006
  • First published August 16, 2006.
  • Version of record published August 16, 2006.
Copyright & Usage 
Copyright © 2006 Society for Neuroscience 0270-6474/06/268484-08$15.00/0

Author Information

  1. Yo Sasaki1,
  2. Toshiyuki Araki2, and
  3. Jeffrey Milbrandt1
  1. 1Departments of Pathology and Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, and 2Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
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Author contributions

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Disclosures

    • Received June 1, 2006.
    • Revision received June 27, 2006.
    • Accepted July 3, 2006.
  • This work was supported by the Hope Center for Neurological Disorders, National Institutes of Health Grants AG13730, NS39358, and NS049087, and Muscular Dystrophy Association Grant 3972 (J.M.). We thank Kelli Simburger and Tim Fahrner for experimental assistance, members of the Milbrandt laboratory for their comments on this manuscript, and E. Johnson and S. Imai for helpful discussions. We and Washington University may derive benefit from a licensing agreement with Sirtris Pharmaceuticals, which did not provide any support for this work.

  • Correspondence should be addressed to Jeffrey Milbrandt, Departments of Pathology and Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110. Email: jmilbrandt{at}wustl.edu

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Jun 202564418
Jul 202545525
Aug 202544032
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Total 202561721212
Total139852841454
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The Journal of Neuroscience: 26 (33)
Journal of Neuroscience
Vol. 26, Issue 33
16 Aug 2006
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Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy
Yo Sasaki, Toshiyuki Araki, Jeffrey Milbrandt
Journal of Neuroscience 16 August 2006, 26 (33) 8484-8491; DOI: 10.1523/JNEUROSCI.2320-06.2006

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Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy
Yo Sasaki, Toshiyuki Araki, Jeffrey Milbrandt
Journal of Neuroscience 16 August 2006, 26 (33) 8484-8491; DOI: 10.1523/JNEUROSCI.2320-06.2006
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Keywords

  • axotomy
  • neuropathology
  • neuroprotection
  • dorsal root ganglion
  • nucleus
  • GFP

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