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Articles, Neurobiology of Disease

Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease

Kim N. Green, Lauren M. Billings, Benno Roozendaal, James L. McGaugh and Frank M. LaFerla
Journal of Neuroscience 30 August 2006, 26 (35) 9047-9056; DOI: https://doi.org/10.1523/JNEUROSCI.2797-06.2006
Kim N. Green
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Lauren M. Billings
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Benno Roozendaal
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James L. McGaugh
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Frank M. LaFerla
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2797-06.2006
PubMed 
16943563
Published By 
Society for Neuroscience
History 
  • Received April 11, 2006
  • Accepted July 23, 2006
  • First published August 30, 2006.
  • Version of record published August 30, 2006.
Copyright & Usage 
Copyright © 2006 Society for Neuroscience 0270-6474/06/269047-10$15.00/0

Author Information

  1. Kim N. Green,
  2. Lauren M. Billings,
  3. Benno Roozendaal,
  4. James L. McGaugh, and
  5. Frank M. LaFerla
  1. Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697-4545
  1. Correspondence should be addressed to Frank M. LaFerla, Department of Neurobiology and Behavior, University of California, Irvine, 1109 Gillespie Neuroscience Building, Irvine, CA 92697-4545. laferla{at}uci.edu
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Author contributions

Disclosures

    • Received April 11, 2006.
    • Accepted July 23, 2006.
  • This work was supported in part by grants from Alzheimer’s Association, National Institute of Health Grant AG0212982 (F.M.L.), and National Institute of Mental Health Grant MH-12526 (J.L.M.). We thank Drs. Masashi Kitazawa, Salvatore Oddo, and Mathew Blurton-Jones for helpful discussion and Andrew Huy Tran for technical assistance.

  • Correspondence should be addressed to Frank M. LaFerla, Department of Neurobiology and Behavior, University of California, Irvine, 1109 Gillespie Neuroscience Building, Irvine, CA 92697-4545. laferla{at}uci.edu

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The Journal of Neuroscience: 26 (35)
Journal of Neuroscience
Vol. 26, Issue 35
30 Aug 2006
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Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease
Kim N. Green, Lauren M. Billings, Benno Roozendaal, James L. McGaugh, Frank M. LaFerla
Journal of Neuroscience 30 August 2006, 26 (35) 9047-9056; DOI: 10.1523/JNEUROSCI.2797-06.2006

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Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease
Kim N. Green, Lauren M. Billings, Benno Roozendaal, James L. McGaugh, Frank M. LaFerla
Journal of Neuroscience 30 August 2006, 26 (35) 9047-9056; DOI: 10.1523/JNEUROSCI.2797-06.2006
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  • This could be due to a reduced DHEA to cortisol ratio...
    James M. Howard
    Published on: 21 June 2007
  • Published on: (21 June 2007)
    Page navigation anchor for This could be due to a reduced DHEA to cortisol ratio...
    This could be due to a reduced DHEA to cortisol ratio...
    • James M. Howard, Biologist, independent

    In 1985, I first suggested that Alzheimer's disease may be due to low DHEA (1). In the same place, I suggested that cortisol evolved to counteract the effects of DHEA and that this is the basis of the "fight or flight" mechanism. This may explain why prolonged exposure to cortisol is so harmful because this means that DHEA is not exerting sufficient effects to counteract the negative effects of cortisol. DHEA naturally b...

    Show More

    In 1985, I first suggested that Alzheimer's disease may be due to low DHEA (1). In the same place, I suggested that cortisol evolved to counteract the effects of DHEA and that this is the basis of the "fight or flight" mechanism. This may explain why prolonged exposure to cortisol is so harmful because this means that DHEA is not exerting sufficient effects to counteract the negative effects of cortisol. DHEA naturally begins to decline around age twenty, reaching very low levels in aging while cortisol levels do not decline as dramatically. This may explain the findings of Green, et al.

    1."A Theory of the Control of the Ontogeny and Phylogeny of Homo sapiens bythe Interaction of Dehydroepiandrosterone and the Amygdala," Copyright 1985, James Michael Howard, Fayetteville, Arkansas, Registration No. TXu 220 580

    Show Less
    Competing Interests: None declared.

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