Articles, Neurobiology of Disease

Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease

Kim N. Green, Lauren M. Billings, Benno Roozendaal, James L. McGaugh and Frank M. LaFerla
Journal of Neuroscience 30 August 2006, 26 (35) 9047-9056; DOI: https://doi.org/10.1523/JNEUROSCI.2797-06.2006

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  • Submitted on: (21 June 2007)
    Page navigation anchor for This could be due to a reduced DHEA to cortisol ratio...
    This could be due to a reduced DHEA to cortisol ratio...

    In 1985, I first suggested that Alzheimer's disease may be due to low DHEA (1). In the same place, I suggested that cortisol evolved to counteract the effects of DHEA and that this is the basis of the "fight or flight" mechanism. This may explain why prolonged exposure to cortisol is so harmful because this means that DHEA is not exerting sufficient effects to counteract the negative effects of cortisol. DHEA naturally b...

    Show More
    Competing Interests: None declared.
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Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease
Kim N. Green, Lauren M. Billings, Benno Roozendaal, James L. McGaugh, Frank M. LaFerla
Journal of Neuroscience 30 August 2006, 26 (35) 9047-9056; DOI: 10.1523/JNEUROSCI.2797-06.2006
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  • Published on: (21 June 2007)
    Page navigation anchor for This could be due to a reduced DHEA to cortisol ratio...
    This could be due to a reduced DHEA to cortisol ratio...

    In 1985, I first suggested that Alzheimer's disease may be due to low DHEA (1). In the same place, I suggested that cortisol evolved to counteract the effects of DHEA and that this is the basis of the "fight or flight" mechanism. This may explain why prolonged exposure to cortisol is so harmful because this means that DHEA is not exerting sufficient effects to counteract the negative effects of cortisol. DHEA naturally b...

    Show More
    Competing Interests: None declared.