Cover Legend: A merged image taken by confocal microscopy showing the extent of infiltration (Hoechst 33258; blue), demyelination (myelin basic protein; green), and axonal loss (neurofilament 200; red) in a lesion site of the lumbar spinal cord of a Wld^S mouse with induced experimental autoimmune encephalomyelitis (EAE). Many axons are preserved within the EAE lesions in Wld^S but not wild-type mice. For details, see the article by Kaneko et al. in this issue (pages 9794–9804).