Figure 4.
NMDARs mediate SSE in SCs. SSE was assessed after bath application of the mGluR1 antagonist CPCCOEt (A, B), the NMDAR antagonist CPP (C, D), and coapplication of CPCCOEt and CPP (E, F). A, C, E, The extent of SSE for five to seven experiments in each condition is summarized during bath application of drugs (left); average synaptic currents from representative experiments are shown in control conditions and in the presence of antagonists (right). B, D, F, Summary of the effects of CPCCOEt (B), CPP (D), and CPCCOEt plus CPP (F) on the time course of SSE in SCs. G, Summary of the average SSE after conditioning trains (normalized to baseline) in PCs and SCs for control conditions, in the presence of 2 μm AM251, 100 μm CPCCOEt, 5 μm CPP, and after coapplication of CPCCOEt and CPP and CPCCOEt and 50 μm D-AP5. CPCCOEt application led to a statistically significant difference in SSE between SCs and PCs (p < 0.01; unpaired Student's t test). SSE was significantly reduced in SCs after the coapplication of CPCCOEt and CPP and CPCCOEt and D-AP5 (p < 0.01; paired Student's t test). H, Summary of the effects of CPCCOEt on SSE in PCs. norm., Normalized.
