Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

This work was supported by National Institute on Aging Grants P01 AG021184 (Project 1, L.V.E.; Project 4, R.V.; Histology Core, R.B.) and R01 AG022560 (R.V.) We are indebted to Lynn Doglio and her staff at the Northwestern Transgenic and Targeted Mutagenesis Laboratory for transgene microinjection and production of founder transgenic mice. We also thank the following individuals for their valuable input on this project: Fred Van Leuven for the Thy1 transgene cassette vector, Leong Chew for assistance with confocal imaging, Gopal Thinakaran for the PS1NT antibody, Dennis Selkoe for the R1282 antibody, and Marsel Mesulam, Richard Miller, Gunnar Gouras, Frank Laferla, and Sam Sisodia for thoughtful comments on this manuscript.