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Articles, Neurobiology of Disease

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Pei Shao, Jeffery Craft, Angela Guillozet-Bongaarts, Masuo Ohno, John Disterhoft, Linda Van Eldik, Robert Berry and Robert Vassar
Journal of Neuroscience 4 October 2006, 26 (40) 10129-10140; DOI: https://doi.org/10.1523/JNEUROSCI.1202-06.2006
Holly Oakley
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Sarah L. Cole
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Sreemathi Logan
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Erika Maus
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Pei Shao
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Jeffery Craft
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Angela Guillozet-Bongaarts
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Masuo Ohno
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John Disterhoft
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Linda Van Eldik
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Robert Berry
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Robert Vassar
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1202-06.2006
PubMed 
17021169
Published By 
Society for Neuroscience
History 
  • Received March 20, 2006
  • Revision received July 24, 2006
  • Accepted August 24, 2006
  • First published October 4, 2006.
  • Version of record published October 4, 2006.
Copyright & Usage 
Copyright © 2006 Society for Neuroscience 0270-6474/06/2610129-13$15.00/0

Author Information

  1. Holly Oakley1,
  2. Sarah L. Cole1,
  3. Sreemathi Logan1,
  4. Erika Maus1,
  5. Pei Shao1,
  6. Jeffery Craft1,
  7. Angela Guillozet-Bongaarts1,
  8. Masuo Ohno2,
  9. John Disterhoft2,
  10. Linda Van Eldik1,
  11. Robert Berry1, and
  12. Robert Vassar1
  1. Departments of 1Cell and Molecular Biology and
  2. 2Physiology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611
  1. Correspondence should be addressed to Dr. Robert Vassar, Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611. r-vassar{at}northwestern.edu
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Author contributions

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Disclosures

    • Received March 20, 2006.
    • Revision received July 24, 2006.
    • Accepted August 24, 2006.
  • This work was supported by National Institute on Aging Grants P01 AG021184 (Project 1, L.V.E.; Project 4, R.V.; Histology Core, R.B.) and R01 AG022560 (R.V.) We are indebted to Lynn Doglio and her staff at the Northwestern Transgenic and Targeted Mutagenesis Laboratory for transgene microinjection and production of founder transgenic mice. We also thank the following individuals for their valuable input on this project: Fred Van Leuven for the Thy1 transgene cassette vector, Leong Chew for assistance with confocal imaging, Gopal Thinakaran for the PS1NT antibody, Dennis Selkoe for the R1282 antibody, and Marsel Mesulam, Richard Miller, Gunnar Gouras, Frank Laferla, and Sam Sisodia for thoughtful comments on this manuscript.

  • Correspondence should be addressed to Dr. Robert Vassar, Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611. r-vassar{at}northwestern.edu

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Article usage: October 2006 to January 2021

AbstractFullPdf
Oct 20068836041560
Nov 20069398309
Dec 20064546161
Total 200610217482030
Jan 20073542160
Feb 2007156586
Mar 200728194184
Apr 200731196193
May 200718210196
Jun 200720109133
Jul 200714147148
Aug 2007229196
Sep 200715150170
Oct 200731146150
Nov 200724133168
Dec 200715102123
Total 200726815851807
Jan 200827136122
Feb 200830161129
Mar 200830157174
Apr 200845117167
May 200838133168
Jun 200830141146
Jul 200835149175
Aug 200841129135
Sep 2008101141120
Oct 200860126122
Nov 200878150136
Dec 2008389096
Total 200855316301690
Jan 200944114115
Feb 200936131141
Mar 200944125120
Apr 200952144176
May 200925104136
Jun 200920141123
Jul 200929110106
Aug 200928105109
Sep 200937166148
Oct 200948167172
Nov 200986169206
Dec 200972111105
Total 200952115871657
Jan 201080135164
Feb 201032125152
Mar 201049174142
Apr 201065337194
May 201065229187
Jun 201056165149
Jul 201056135148
Aug 201043109116
Sep 201046130150
Oct 201061153152
Nov 201054160162
Dec 201063163166
Total 201067020151882
Jan 201174187166
Feb 201146179168
Mar 201179193113
Apr 201166211161
May 20114714796
Jun 201169198153
Jul 20114214697
Aug 201175175120
Sep 201192153116
Oct 201188178130
Nov 201195143132
Dec 201178143114
Total 201185120531566
Jan 2012108215155
Feb 2012104206148
Mar 2012105261176
Apr 2012101254301
May 201276230409
Jun 2012163222141
Jul 2012116263136
Aug 201258218124
Sep 201268228134
Oct 201292271186
Nov 2012126256164
Dec 2012121173153
Total 2012123827972227
Jan 2013132273182
Feb 2013109213916
Mar 2013186264696
Apr 2013125233181
May 201380318177
Jun 201387727131
Jul 201361408128
Aug 2013141384127
Sep 2013107473123
Oct 2013214592165
Nov 2013181195136
Dec 201382172107
Total 2013150542523069
Jan 2014135204147
Feb 2014131192112
Mar 2014133235157
Apr 2014175219170
May 2014120195148
Jun 2014114252135
Jul 201494230130
Aug 201487246114
Sep 201482252120
Oct 201493210109
Nov 2014106315132
Dec 2014108232139
Total 2014137827821613
Jan 2015120281421
Feb 2015113279169
Mar 2015117406188
Apr 2015144377125
May 2015109302136
Jun 201577307132
Jul 2015119370151
Aug 201575308114
Sep 201594375154
Oct 2015107324183
Nov 2015123282160
Dec 2015126303157
Total 2015132439142090
Jan 2016136379239
Feb 2016156372205
Mar 2016201352186
Apr 2016110291162
May 2016131346192
Jun 2016124310177
Jul 2016110294147
Aug 2016104285154
Sep 2016113340170
Oct 2016129374241
Nov 201684322254
Dec 201677415877
Total 2016147540803004
Jan 201760586318
Feb 201787625252
Mar 201761670320
Apr 201767529183
May 201789598212
Jun 201770518218
Jul 201746462196
Aug 201737456162
Sep 201737367183
Oct 201789453213
Nov 201782422199
Dec 201770329173
Total 201779560152629
Jan 201860495270
Feb 201862457224
Mar 201888491268
Apr 201896520254
May 201883620285
Jun 201857561262
Jul 201845627201
Aug 201847563258
Sep 201867617261
Oct 2018117629301
Nov 201899642276
Dec 201871923242
Total 201889271453102
Jan 201989893274
Feb 201957635307
Mar 201984678334
Apr 201990610283
May 201976519265
Jun 201960635262
Jul 201955593226
Aug 201969487206
Sep 201944402166
Oct 201973613203
Nov 201953427209
Dec 201944311141
Total 201979468032876
Jan 202041406165
Feb 202040518189
Mar 202064390211
Apr 202055424234
May 202070413280
Jun 202034301147
Jul 202038318224
Aug 202029289133
Sep 202046549193
Oct 202075438219
Nov 202076577249
Dec 202061514298
Total 202062951372542
Jan 202125241139
Total 202125241139
Total139395278433923
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The Journal of Neuroscience: 26 (40)
Journal of Neuroscience
Vol. 26, Issue 40
4 Oct 2006
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Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
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Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Pei Shao, Jeffery Craft, Angela Guillozet-Bongaarts, Masuo Ohno, John Disterhoft, Linda Van Eldik, Robert Berry, Robert Vassar
Journal of Neuroscience 4 October 2006, 26 (40) 10129-10140; DOI: 10.1523/JNEUROSCI.1202-06.2006

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Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
Holly Oakley, Sarah L. Cole, Sreemathi Logan, Erika Maus, Pei Shao, Jeffery Craft, Angela Guillozet-Bongaarts, Masuo Ohno, John Disterhoft, Linda Van Eldik, Robert Berry, Robert Vassar
Journal of Neuroscience 4 October 2006, 26 (40) 10129-10140; DOI: 10.1523/JNEUROSCI.1202-06.2006
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