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Articles, Neurobiology of Disease

Impaired Inactivation Gate Stabilization Predicts Increased Persistent Current for an Epilepsy-Associated SCN1A Mutation

Kristopher M. Kahlig, Sunita N. Misra and Alfred L. George Jr
Journal of Neuroscience 25 October 2006, 26 (43) 10958-10966; https://doi.org/10.1523/JNEUROSCI.3378-06.2006
Kristopher M. Kahlig
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Sunita N. Misra
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Alfred L. George Jr
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3378-06.2006
PubMed 
17065438
Published By 
Society for Neuroscience
History 
  • Received June 6, 2006
  • Revision received September 11, 2006
  • Accepted September 11, 2006
  • First published October 25, 2006.
  • Version of record published October 25, 2006.
Copyright & Usage 
Copyright © 2006 Society for Neuroscience 0270-6474/06/2610958-09$15.00/0

Author Information

  1. Kristopher M. Kahlig1,
  2. Sunita N. Misra2, and
  3. Alfred L. George Jr1,2
  1. 1Division of Genetic Medicine, Department of Medicine, and
  2. 2Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232-0275
  1. Correspondence should be addressed to Dr. Alfred L. George Jr, Division of Genetic Medicine, 529 Light Hall, Vanderbilt University, 2215 Garland Avenue, Nashville, TN 37232-0275. al.george{at}vanderbilt.edu
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Author contributions

Disclosures

    • Received June 6, 2006.
    • Revision received September 11, 2006.
    • Accepted September 11, 2006.
  • This work was supported by a research grant from the National Institutes of Health (NS32387 to A.L.G.), an institutional training grant from the National Institute of Mental Health (T32-MH065215 to K.M.K.), and an Epilepsy Foundation research training fellowship (4-04-353-6242 to S.N.M.). A.L.G. is a recipient of a Javits Neuroscience Award from the National Institute of Neurological Diseases and Stroke. We thank Dr. Carlos Vanoye for critical review of this manuscript and Daniel Kaiser for help with computational model development.

  • Correspondence should be addressed to Dr. Alfred L. George Jr, Division of Genetic Medicine, 529 Light Hall, Vanderbilt University, 2215 Garland Avenue, Nashville, TN 37232-0275. al.george{at}vanderbilt.edu

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Total 202517264109
Total1432153573
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The Journal of Neuroscience: 26 (43)
Journal of Neuroscience
Vol. 26, Issue 43
25 Oct 2006
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Impaired Inactivation Gate Stabilization Predicts Increased Persistent Current for an Epilepsy-Associated SCN1A Mutation
Kristopher M. Kahlig, Sunita N. Misra, Alfred L. George Jr
Journal of Neuroscience 25 October 2006, 26 (43) 10958-10966; DOI: 10.1523/JNEUROSCI.3378-06.2006

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Impaired Inactivation Gate Stabilization Predicts Increased Persistent Current for an Epilepsy-Associated SCN1A Mutation
Kristopher M. Kahlig, Sunita N. Misra, Alfred L. George Jr
Journal of Neuroscience 25 October 2006, 26 (43) 10958-10966; DOI: 10.1523/JNEUROSCI.3378-06.2006
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