Enhancing GABAA Receptor α1 Subunit Levels in Hippocampal Dentate Gyrus Inhibits Epilepsy Development in an Animal Model of Temporal Lobe Epilepsy

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¹Division of Neurology, Pediatric Regional Epilepsy Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104,
²Neuroscience Graduate Group,
³Center for Comparative Medical Genetics, School of Veterinary Medicine, and
Departments of ⁴Neurology and
⁵Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and
⁶Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, and
⁷Program in Biomedical Neurosciences, Boston University School of Medicine, Boston, Massachusetts 02118

Correspondence should be addressed to either of the following: Dr. Amy R. Brooks-Kayal, Children's Hospital of Philadelphia, Division of Neurology, Abramson Pediatric Research Center, Room 502, 3615 Civic Center Boulevard, Philadelphia, PA 19104, kayal{at}email.chop.edu; or Dr. Shelley J. Russek, Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, srussek{at}bu.edu

This work was supported by National Institutes of Health Grants NS38595 (A.R.B.-K.), NS051710 (A.R.B.-K., S.J.R.), NS050393 (S.J.R., A.R.B.-K.), NS51943 (I.V.L.), NS38690 (J.H.W.), DK47757 (J.H.W.), and DK63973 (J.H.W.) and a grant from the American Epilepsy Society (A.R.B.K., S.J.R.). Funding for statistical support was provided by the Mental Retardation and Developmental Disability Research Center of the Children's Hospital of Philadelphia (Grant P30 HD26979). We are very appreciative for the statistical expertise of Dr. Paul Gallagher in the Division of Biostatistics, Department of Pediatrics at Children's Hospital of Philadelphia.
Correspondence should be addressed to either of the following: Dr. Amy R. Brooks-Kayal, Children's Hospital of Philadelphia, Division of Neurology, Abramson Pediatric Research Center, Room 502, 3615 Civic Center Boulevard, Philadelphia, PA 19104, kayal{at}email.chop.edu; or Dr. Shelley J. Russek, Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, srussek{at}bu.edu

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