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Articles, Neurobiology of Disease

Inhibition of Caspase-Mediated Apoptosis by Peroxynitrite in Traumatic Brain Injury

Anthony Lau, Mark Arundine, Hong-Shuo Sun, Michael Jones and Michael Tymianski
Journal of Neuroscience 8 November 2006, 26 (45) 11540-11553; DOI: https://doi.org/10.1523/JNEUROSCI.3507-06.2006
Anthony Lau
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Mark Arundine
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Hong-Shuo Sun
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Michael Jones
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Michael Tymianski
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Figure 3.

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Figure 3.

Stretch plus 30 μm NMDA nitrates procaspase-3. A–C, Whole-cell lysates from cultures exposed to stretch plus 30 μm NMDA were immunoprecipitated using an agarose-bound monoclonal anti-3-nitrotyrosine antibody and run on immunoblots (middle lanes) along with nonimmunoprecipitated samples from staurosporine-treated cultures as positive controls and from untreated cultures as negative controls. A, Anti-caspase-9 antibody. B, Anti-Apaf-1 antibody. C, Anti-caspase-3 (pro- and active/cleaved forms). n = 2 experiments/blot. The dotted line encompasses the lanes containing the immunoprecipitated sample. The untreated and staurosporine controls were not immunoprecipitated with anti-3-NT antibodies as, in the absence of nitration, these proteins cannot be precipitated with the antibody-agarose conjugate.

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The Journal of Neuroscience: 43 (39)
Journal of Neuroscience
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27 Sep 2023
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