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Articles, Cellular/Molecular

Biophysical Model of AMPA Receptor Trafficking and Its Regulation during Long-Term Potentiation/Long-Term Depression

Berton A. Earnshaw and Paul C. Bressloff
Journal of Neuroscience 22 November 2006, 26 (47) 12362-12373; https://doi.org/10.1523/JNEUROSCI.3601-06.2006
Berton A. Earnshaw
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Paul C. Bressloff
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Abstract

AMPA receptors mediate the majority of fast excitatory synaptic transmission in the CNS, and evidence suggests that AMPA receptor trafficking regulates synaptic strength, a phenomenon implicated in learning and memory. There are two major mechanisms of AMPA receptor trafficking: exocytic/endocytic exchange of surface receptors with intracellular receptor pools, and the lateral diffusion or hopping of surface receptors between the postsynaptic density and the surrounding extrasynaptic membrane. In this paper, we present a biophysical model of these trafficking mechanisms under basal conditions and during the expression of long-term potentiation (LTP) and depression (LTD). We show how our model reproduces a wide range of physiological data, and use this to make predictions regarding possible targets of second-messenger pathways activated during the induction phase of LTP/LTD.

  • AMPA receptor trafficking
  • long-term potentiation
  • long-term depression
  • synaptic plasticity
  • exocytosis/endocytosis
  • membrane diffusion
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The Journal of Neuroscience: 26 (47)
Journal of Neuroscience
Vol. 26, Issue 47
22 Nov 2006
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Biophysical Model of AMPA Receptor Trafficking and Its Regulation during Long-Term Potentiation/Long-Term Depression
Berton A. Earnshaw, Paul C. Bressloff
Journal of Neuroscience 22 November 2006, 26 (47) 12362-12373; DOI: 10.1523/JNEUROSCI.3601-06.2006

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Biophysical Model of AMPA Receptor Trafficking and Its Regulation during Long-Term Potentiation/Long-Term Depression
Berton A. Earnshaw, Paul C. Bressloff
Journal of Neuroscience 22 November 2006, 26 (47) 12362-12373; DOI: 10.1523/JNEUROSCI.3601-06.2006
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