The Lipoprotein Receptor LR11 Regulates Amyloid β Production and Amyloid Precursor Protein Traffic in Endosomal Compartments

Katrin Offe; Sara E. Dodson; James T. Shoemaker; Jason J. Fritz; Marla Gearing; Allan I. Levey; James J. Lah

doi:10.1523/JNEUROSCI.4946-05.2006

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.4946-05.2006

PubMed

16452683

Published By

Society for Neuroscience

History

Received September 18, 2005
Revision received December 16, 2005
Accepted December 19, 2005
First published February 1, 2006.

Version of record published February 1, 2006.

Author Information

Katrin Offe¹,²,
Sara E. Dodson¹,²,
James T. Shoemaker¹,⁴,
Jason J. Fritz¹,⁴,
Marla Gearing¹,³,
Allan I. Levey¹,⁴, and
James J. Lah¹,⁴

¹Center for Neurodegenerative Disease, ²Graduate Program in Neuroscience, and ³Departments of Pathology and ⁴Neurology, Emory University, Atlanta, Georgia 30322

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Author contributions

Disclosures

Received September 18, 2005.
Revision received December 16, 2005.
Accepted December 19, 2005.

This work was supported by National Institutes of Health–National Institute on Aging Grants R01 AG024214 and P50 AG025688. We thank Howard D. Rees and Hong Yi for excellent technical assistance. We thank Drs. H. Bujo, W. J. Schneider, D. Selkoe, and C. Schaller for sharing reagents.
Correspondence should be addressed to Dr. James J. Lah, Center for Neurodegenerative Disease, 615 Michael Street, Suite 505 South, Atlanta, GA 30322. Email: jlah{at}emory.edu

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	Abstract	Full	Pdf
Feb 2006	393	269	444
Mar 2006	50	81	99
Apr 2006	13	82	56
May 2006	15	69	72
Jun 2006	10	38	32
Jul 2006	8	53	51
Aug 2006	7	76	51
Sep 2006	18	68	50
Oct 2006	8	69	61
Nov 2006	20	80	48
Dec 2006	9	31	27
Total 2006	551	916	991
Jan 2007	27	232	210
Feb 2007	16	143	91
Mar 2007	10	113	93
Apr 2007	18	84	52
May 2007	12	68	58
Jun 2007	14	50	43
Jul 2007	15	45	25
Aug 2007	13	46	30
Sep 2007	15	76	45
Oct 2007	11	49	47
Nov 2007	13	57	38
Dec 2007	7	62	31
Total 2007	171	1025	763
Jan 2008	16	67	38
Feb 2008	21	38	27
Mar 2008	17	53	42
Apr 2008	24	49	34
May 2008	26	52	32
Jun 2008	21	53	29
Jul 2008	29	33	26
Aug 2008	48	43	32
Sep 2008	51	65	32
Oct 2008	34	39	26
Nov 2008	35	56	40
Dec 2008	6	35	25
Total 2008	328	583	383
Jan 2009	21	32	15
Feb 2009	18	45	17
Mar 2009	66	24	12
Apr 2009	30	29	14
May 2009	18	24	16
Jun 2009	13	27	12
Jul 2009	28	33	16
Aug 2009	21	16	11
Sep 2009	12	24	21
Oct 2009	29	14	21
Nov 2009	52	37	28
Dec 2009	72	15	16
Total 2009	380	320	199
Jan 2010	67	16	23
Feb 2010	33	22	16
Mar 2010	30	37	19
Apr 2010	19	55	30
May 2010	33	38	32
Jun 2010	15	31	25
Jul 2010	29	35	9
Aug 2010	37	29	27
Sep 2010	26	21	24
Oct 2010	21	24	17
Nov 2010	18	22	18
Dec 2010	19	27	21
Total 2010	347	357	261
Jan 2011	16	28	25
Feb 2011	14	13	10
Mar 2011	26	27	25
Apr 2011	14	31	20
May 2011	19	17	17
Jun 2011	13	12	18
Jul 2011	19	13	27
Aug 2011	13	8	24
Sep 2011	23	9	14
Oct 2011	23	26	32
Nov 2011	28	22	19
Dec 2011	22	13	14
Total 2011	230	219	245
Jan 2012	25	11	19
Feb 2012	17	11	23
Mar 2012	26	28	13
Apr 2012	29	17	25
May 2012	18	19	12
Jun 2012	26	17	16
Jul 2012	17	18	11
Aug 2012	19	23	13
Sep 2012	19	9	11
Oct 2012	16	27	17
Nov 2012	58	16	8
Dec 2012	54	17	10
Total 2012	324	213	178
Jan 2013	32	13	13
Feb 2013	28	13	8
Mar 2013	45	18	10
Apr 2013	41	27	14
May 2013	20	24	9
Jun 2013	34	15	12
Jul 2013	18	19	11
Aug 2013	23	36	6
Sep 2013	34	35	11
Oct 2013	33	45	19
Nov 2013	25	36	14
Dec 2013	21	44	8
Total 2013	354	325	135
Jan 2014	28	95	8
Feb 2014	44	102	10
Mar 2014	35	100	10
Apr 2014	35	105	9
May 2014	37	115	12
Jun 2014	35	59	5
Jul 2014	37	104	7
Aug 2014	18	91	8
Sep 2014	21	56	4
Oct 2014	24	40	12
Nov 2014	24	33	5
Dec 2014	37	27	6
Total 2014	375	927	96
Jan 2015	20	28	8
Feb 2015	42	17	3
Mar 2015	27	16	13
Apr 2015	30	24	6
May 2015	17	20	8
Jun 2015	29	39	8
Jul 2015	15	28	9
Aug 2015	40	30	13
Sep 2015	18	63	10
Oct 2015	27	18	5
Nov 2015	30	16	2
Dec 2015	37	14	7
Total 2015	332	313	92
Jan 2016	41	17	10
Feb 2016	30	15	11
Mar 2016	30	19	17
Apr 2016	25	18	4
May 2016	23	20	7
Jun 2016	17	23	5
Jul 2016	15	23	7
Aug 2016	24	23	2
Sep 2016	18	19	4
Oct 2016	11	23	11
Nov 2016	5	35	5
Dec 2016	1	25	9
Total 2016	240	260	92
Jan 2017	1	21	3
Feb 2017	9	26	10
Mar 2017	0	36	15
Apr 2017	3	19	8
May 2017	1	44	4
Jun 2017	2	19	4
Jul 2017	6	18	6
Aug 2017	2	20	4
Sep 2017	3	13	5
Oct 2017	4	13	6
Nov 2017	3	24	2
Dec 2017	3	7	5
Total 2017	37	260	72
Jan 2018	1	19	4
Feb 2018	5	16	9
Mar 2018	2	10	5
Apr 2018	5	27	4
May 2018	1	31	13
Jun 2018	7	37	16
Jul 2018	2	14	7
Aug 2018	1	19	2
Sep 2018	1	24	5
Oct 2018	1	21	8
Nov 2018	5	22	10
Dec 2018	0	13	0
Total 2018	31	253	83
Jan 2019	4	23	8
Feb 2019	4	16	9
Mar 2019	1	26	9
Apr 2019	3	33	8
May 2019	4	26	8
Jun 2019	2	24	5
Jul 2019	4	17	13
Aug 2019	7	39	21
Sep 2019	1	72	5
Oct 2019	7	114	12
Nov 2019	3	27	11
Dec 2019	5	24	8
Total 2019	45	441	117
Jan 2020	1	32	5
Feb 2020	5	16	6
Mar 2020	2	25	14
Apr 2020	2	14	7
May 2020	2	30	10
Jun 2020	2	23	9
Jul 2020	4	18	6
Aug 2020	3	26	5
Sep 2020	3	18	4
Oct 2020	4	34	11
Nov 2020	5	35	21
Dec 2020	10	27	10
Total 2020	43	298	108
Jan 2021	7	49	20
Feb 2021	1	48	12
Mar 2021	4	39	18
Apr 2021	7	33	7
May 2021	6	33	10
Jun 2021	3	25	8
Jul 2021	1	24	12
Total 2021	29	251	87
Total	3817	6961	3902