Cover legend: Binding of a recombinant fragment of myosin-1c (Myo1c) (green), a component of the hair-cell transduction complex, to an isolated bullfrog saccular hair cell. Filamentous actin is stained in red to delineate the actin-filled stereocilia that comprise the mechanosensitive hair bundle. Note the intense binding of Myo1c to receptors at the tips of stereocilia, the site of hair-cell transduction, as well as binding within the soma. For more information, see the article by Phillips et al. in the October 18, 2006 issue (pages 10777–10788).