Subcutaneous Nogo Receptor Removes Brain Amyloid-β and Improves Spatial Memory in Alzheimer's Transgenic Mice

James H. Park; Gabriel A. Widi; David A. Gimbel; Noam Y. Harel; Daniel H. S. Lee; Stephen M. Strittmatter

doi:10.1523/JNEUROSCI.4504-06.2006

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.4504-06.2006

PubMed

17182778

Published By

Society for Neuroscience

History

Received August 10, 2006
Accepted November 12, 2006
First published December 20, 2006.

Version of record published December 20, 2006.

Author Information

James H. Park¹,
Gabriel A. Widi¹,
David A. Gimbel¹,
Noam Y. Harel¹,
Daniel H. S. Lee², and
Stephen M. Strittmatter¹

¹Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, and
²Biogen Idec, Cambridge, Massachusetts 02140

Correspondence should be addressed to Stephen M. Strittmatter, Department of Neurology, Yale University School of Medicine, P.O. Box 208018, New Haven, CT 06510. stephen.strittmatter{at}yale.edu

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Author contributions

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Disclosures

Received August 10, 2006.
Accepted November 12, 2006.

This work was supported by grants from the National Institutes of Health (NIH) to S.M.S. and by an institutional NIH Medical Scientist Training grant to J.H.P. S.M.S. is a member of the Kavli Institute of Neuroscience at Yale University. We thank Dave Morgan for counsel regarding radial arm water maze testing.
Correspondence should be addressed to Stephen M. Strittmatter, Department of Neurology, Yale University School of Medicine, P.O. Box 208018, New Haven, CT 06510. stephen.strittmatter{at}yale.edu

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	Abstract	Full	Pdf
Dec 2006	592	139	399
Total 2006	592	139	399
Jan 2007	173	214	297
Feb 2007	37	117	99
Mar 2007	35	81	84
Apr 2007	20	73	68
May 2007	12	56	36
Jun 2007	24	53	47
Jul 2007	11	56	50
Aug 2007	11	57	35
Sep 2007	12	57	40
Oct 2007	10	35	38
Nov 2007	14	51	32
Dec 2007	8	62	44
Total 2007	367	912	870
Jan 2008	7	48	45
Feb 2008	9	39	31
Mar 2008	15	50	34
Apr 2008	11	34	25
May 2008	12	54	39
Jun 2008	11	29	26
Jul 2008	28	48	34
Aug 2008	20	44	23
Sep 2008	55	37	27
Oct 2008	41	44	30
Nov 2008	44	19	15
Dec 2008	7	16	9
Total 2008	260	462	338
Jan 2009	9	27	22
Feb 2009	13	31	20
Mar 2009	29	38	32
Apr 2009	10	37	28
May 2009	13	40	31
Jun 2009	12	34	22
Jul 2009	17	24	15
Aug 2009	13	22	19
Sep 2009	3	11	9
Oct 2009	14	26	18
Nov 2009	39	31	19
Dec 2009	58	18	18
Total 2009	230	339	253
Jan 2010	31	28	14
Feb 2010	18	20	18
Mar 2010	9	37	31
Apr 2010	12	19	21
May 2010	17	16	8
Jun 2010	20	19	20
Jul 2010	25	19	10
Aug 2010	54	20	19
Sep 2010	24	13	11
Oct 2010	25	21	14
Nov 2010	7	9	13
Dec 2010	10	8	10
Total 2010	252	229	189
Jan 2011	7	12	11
Feb 2011	8	13	6
Mar 2011	20	27	55
Apr 2011	10	10	11
May 2011	14	19	18
Jun 2011	4	7	24
Jul 2011	14	3	17
Aug 2011	16	12	22
Sep 2011	30	4	8
Oct 2011	13	13	16
Nov 2011	20	9	20
Dec 2011	18	14	14
Total 2011	174	143	222
Jan 2012	14	8	10
Feb 2012	24	13	11
Mar 2012	21	6	6
Apr 2012	13	12	11
May 2012	15	6	13
Jun 2012	15	5	9
Jul 2012	9	7	16
Aug 2012	5	8	8
Sep 2012	20	12	16
Oct 2012	5	5	9
Nov 2012	23	10	12
Dec 2012	33	5	7
Total 2012	197	97	128
Jan 2013	12	12	10
Feb 2013	13	6	10
Mar 2013	23	17	13
Apr 2013	10	1	4
May 2013	20	8	10
Jun 2013	9	8	6
Jul 2013	27	4	1
Aug 2013	5	6	6
Sep 2013	14	6	9
Oct 2013	24	6	9
Nov 2013	17	11	17
Dec 2013	18	13	7
Total 2013	192	98	102
Jan 2014	23	45	6
Feb 2014	24	35	9
Mar 2014	20	38	9
Apr 2014	42	31	10
May 2014	18	16	6
Jun 2014	22	22	8
Jul 2014	29	35	11
Aug 2014	5	28	7
Sep 2014	8	14	6
Oct 2014	18	17	6
Nov 2014	31	16	6
Dec 2014	12	15	5
Total 2014	252	312	89
Jan 2015	12	20	9
Feb 2015	16	5	3
Mar 2015	23	13	5
Apr 2015	16	5	3
May 2015	6	8	2
Jun 2015	11	8	8
Jul 2015	5	8	3
Aug 2015	13	11	3
Sep 2015	10	6	3
Oct 2015	11	13	8
Nov 2015	11	5	2
Dec 2015	17	2	2
Total 2015	151	104	51
Jan 2016	33	7	11
Feb 2016	10	7	8
Mar 2016	21	13	16
Apr 2016	21	9	10
May 2016	19	8	2
Jun 2016	11	16	5
Jul 2016	9	39	4
Aug 2016	20	6	6
Sep 2016	17	5	5
Oct 2016	8	14	4
Nov 2016	10	10	9
Dec 2016	1	8	0
Total 2016	180	142	80
Jan 2017	3	19	5
Feb 2017	1	10	3
Mar 2017	1	30	5
Apr 2017	6	11	5
May 2017	1	28	5
Jun 2017	4	24	4
Jul 2017	1	11	1
Aug 2017	1	43	2
Sep 2017	0	190	10
Oct 2017	3	115	7
Nov 2017	0	9	4
Dec 2017	5	12	5
Total 2017	26	502	56
Jan 2018	1	6	0
Feb 2018	4	14	4
Mar 2018	0	14	4
Apr 2018	0	13	3
May 2018	2	17	1
Jun 2018	2	14	0
Jul 2018	2	9	3
Aug 2018	0	14	4
Sep 2018	0	18	5
Oct 2018	0	21	5
Nov 2018	2	30	5
Dec 2018	4	14	8
Total 2018	17	184	42
Jan 2019	2	32	8
Feb 2019	6	19	4
Mar 2019	2	39	18
Apr 2019	3	11	8
May 2019	5	11	7
Jun 2019	4	11	5
Jul 2019	1	7	4
Aug 2019	4	24	7
Sep 2019	6	29	4
Oct 2019	2	54	4
Nov 2019	3	21	11
Dec 2019	3	12	5
Total 2019	41	270	85
Jan 2020	4	6	1
Feb 2020	4	14	7
Mar 2020	4	16	2
Apr 2020	4	14	14
May 2020	8	13	8
Jun 2020	2	8	5
Jul 2020	2	11	1
Aug 2020	3	3	9
Sep 2020	4	27	12
Oct 2020	2	30	14
Nov 2020	4	15	2
Dec 2020	9	20	7
Total 2020	50	177	82
Jan 2021	1	17	6
Total 2021	1	17	6
Total	2982	4127	2992