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- supplemental material - Supplementary Figure 1: Apoptosis and BrdU cell labeling remote from lesion site (lumbar cord). Fragmented nuclei in anterogradely degenerated corticospinal tract in lumbar cord by (a) Nissl stain, 9 weeks post-injury,and (b) Hoechst label, 7 months post-lesion. Arrows indicate fragmented nuclei; arrowheads indicate adjacent intact nuclei. (c) BrdU-labeled cells in the anterogradely degenerated corticospinal tract of the lumbar cord double-label for GFAP, indicating differentiation into astrocytes, and (d) double-label for IBA (arrows), indicating differentiation into microglia 7 months post-lesion. Lumbar tracts containing rostrally-projecting axons, such as the dorsal columns, have few BrdU-labeled cells and most of these express microglial markers (not shown). These findings indicate that newly dividing cells at sites remote from a cervical SCI adopt astrocyte and microglial fates rather than oligodendrocyte fates. Scale bar: a,b, 5μm; c,d, 15μm.
- supplemental material - Supplementary Figure 2: Peri-Lesion Regions From All 4 Subjects. Nissl stain; * denotes lesion epicenter. Scale bar = 720 μm.