Silencing of Neuroligin Function by Postsynaptic Neurexins

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¹Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, Physicians and Surgeons 11-511, New York, New York 10032, and
²Center for Neural Science, New York University, New York, New York 10003

Correspondence should be addressed to Peter Scheiffele, Columbia University, Department of Physiology and Cellular Biophysics, 630 West 168th Street, Physicians and Surgeons 11-511, New York, NY 10032. ps2018{at}columbia.edu

H. Taniguchi's present address: Cold Spring Harbor Laboratory, Beckman 220, One Bungtown Road, Cold Spring Harbor, NY 11724.
F. G. Scholl's present address: Department of Physiology and Biophysics, School of Medicine, University of Seville, Avenida Sánchez Pizjúan, 4, 41009 Seville, Spain.
V. Mahadomrongkul's present address: Department of Neuroscience, Albert Einstein Medical College, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461.

H. Taniguchi's present address: Cold Spring Harbor Laboratory, Beckman 220, One Bungtown Road, Cold Spring Harbor, NY 11724.
F. G. Scholl's present address: Department of Physiology and Biophysics, School of Medicine, University of Seville, Avenida Sánchez Pizjúan, 4, 41009 Seville, Spain.
V. Mahadomrongkul's present address: Department of Neuroscience, Albert Einstein Medical College, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461.

This work was supported by awards from The John Merck Fund, the Irma T. Hirschl Trust, the Simons Foundation, and National Institutes of Health Grant R01 NS045014 (P.S.), and National Institutes of Health Grants R01-NS41091 and R01-EY13145 and the New York University Research Challenge Fund (C.A.). H.T. was supported by a Toyobo Biofoundation long-term research fellowship, and L.G. is the recipient of an EMBO long-term fellowship and a senior postdoctoral fellowship from the Charles H. Revson Foundation. We thank Drs. Asim Beg and Karen Wu for comments on this manuscript, Dr. Thomas Jessell, Jennifer Kirkland, and Monica Mendelsohn for generous help with the generation of transgenic mice, Dr. Pico Caroni for sharing the Thy1.2 promoter cassette, Drs. Fiona Doetsch and Hynek Wichterle for sharing equipment, and Dr. Michael Greenberg for EphB2 cDNA.
Correspondence should be addressed to Peter Scheiffele, Columbia University, Department of Physiology and Cellular Biophysics, 630 West 168th Street, Physicians and Surgeons 11-511, New York, NY 10032. ps2018{at}columbia.edu

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