Cover legend: The series are single frames (left to right, top to bottom) from a movie capturing a "naive" acoustic startle response. A balloon was popped behind the subject's head (top right corner in frames 3-5), who was unaware of what would happen, while recording the response at 1000 frames/s. In humans, modulation of the acoustic startle response is impaired in various neuropsychiatric disorders, and in this issue, Burgess and Granato establish larval zebrafish as a genetic model to study prepulse inhibition of the startle response. For more information, see the article by Burgess and Granato in this issue (pages 4984–4994).