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Articles, Cellular/Molecular

Functional Characterization of Intrinsic Cholinergic Interneurons in the Cortex

Jakob von Engelhardt, Marina Eliava, Axel H. Meyer, Andrei Rozov and Hannah Monyer
Journal of Neuroscience 23 May 2007, 27 (21) 5633-5642; DOI: https://doi.org/10.1523/JNEUROSCI.4647-06.2007
Jakob von Engelhardt
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Marina Eliava
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Axel H. Meyer
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Andrei Rozov
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Hannah Monyer
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Figure 8.

Figure 8.
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Figure 8.

Activation of EGFP/ChAT-positive neurons leads to an increase in the frequency of spontaneous EPSCs in pyramidal neurons. A, Spontaneous EPSCs were recorded in a pyramidal neuron (2) before, during, and after activation of an adjacent EGFP/ChAT-positive neurons (1). B, The average increase of spontaneous sEPSC frequency in pyramidal neurons is 0.6 Hz after the activation of the EGFP/ChAT-positive neurons (Δfstim − pre). The increase is significantly different from the change from the pre period to control periods, during which the EGFP/ChAT cell was not stimulated (Δfctr(stim) − pre, Δfctr(post) − pre). There is no significant increase in the sEPSC frequency in the post period (Δfpost − pre). The effect can be blocked with hexamethonium, a blocker of nAChRs. Activation of “control” pyramidal (pyr, 3 in C) cells does not show this effect. The activation of EGFP/ChAT-positive neurons does not alter the frequency of sIPSCs. Error bars indicate ±SEM (p < 0.05). C, Experimental configuration and proposed mechanism. The modulatory effect induced by EGFP/ChAT-positive neuron activation (1) is mediated by presynaptic nAChRs. SEPSCs were recorded in pyramidal cells (2). Stimulation of control pyramidal cells (3).

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The Journal of Neuroscience: 43 (5)
Journal of Neuroscience
Vol. 43, Issue 5
1 Feb 2023
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