Figure 1.
SVZ-derived migratory cells associated with blood vessels. A–B, Coronal sections of the OB showing CTG-positive cells (green) and blood vessels (A; lumen tetramethylrhodamine isothiocyanate fill; red) counterstained with DAPI (B; blue). C–D, Coronal section of P24 mouse OB showing blood vessels (C; red); neuronal precursors (green) exiting the SEL and entering the GCL associate with blood vessels (D; arrows). E–H, Higher-magnification photographs of coronal OB sections showing CTb-labeled cells associated to blood vessels. I, Frequency distribution graph of the number of CTG-positive cells (abscissa) versus distances from the blood vessels (ordinate). The number of CTG-positive cells closer than 3 μm is significantly different from a random distribution (MANOVA, * p < 0.001). Scale bars: (in B) A, B, 200 μm; (in D) C, D, 200 μm; (in H) F–H, 20 μm. MCL, Mitral cell layer; ONL, olfactory nerve layer.