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Articles, Development/Plasticity/Repair

The Nogo-66 Receptor NgR1 Is Required Only for the Acute Growth Cone-Collapsing But Not the Chronic Growth-Inhibitory Actions of Myelin Inhibitors

Onanong Chivatakarn, Shinjiro Kaneko, Zhigang He, Marc Tessier-Lavigne and Roman J. Giger
Journal of Neuroscience 4 July 2007, 27 (27) 7117-7124; DOI: https://doi.org/10.1523/JNEUROSCI.1541-07.2007
Onanong Chivatakarn
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Shinjiro Kaneko
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Zhigang He
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Marc Tessier-Lavigne
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Roman J. Giger
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Figure 4.

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Figure 4.

MAG- and OMgp-induced growth cone collapse is attenuated in NgR1-null neurons. A, Growth cones of postnatal DRG explants of wild-type (NgR1+/+) and NgR1 mutant (NgR1−/−) mice were treated with no inhibitor, AP-Sema3A (10 nm), MAG-Fc (100 nm), or OMgp-Fc (6 nm) for 30 min and stained with rhodamine-conjugated phalloidin. Scale bar, 10 μm. B, Quantification of collapsed growth cones. Results are presented as mean ± SEM from 6–16 independent experiments with NgR1+/+ (black bars) and NgR1−/− (gray bars). For MAG-Fc, n = 6 NgR1+/+ and n = 6 NgR1−/−; for OMgp-Fc, n = 9 NgR1+/+ and n = 10 NgR1−/−; for Sema3A, n = 15 NgR1+/+ and n = 16 NgR1−/−; and for no inhibitor, n = 15 NgR1+/+ and n = 16 NgR1−/−. The number of growth cones quantified for each condition is indicated in parentheses. *p < 0.001, significant difference between NgR1+/+ and NgR1−/− DRG neurons treated with MAG-Fc. **p < 0.001, significant difference between NgR1+/+ and NgR1−/− DRG neurons treated with OMgp-Fc [Kruskal–Wallis one-way ANOVA (post hoc Dunn's test)].

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The Journal of Neuroscience: 43 (22)
Journal of Neuroscience
Vol. 43, Issue 22
31 May 2023
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