Lymphotoxin β Receptor (LtβR): Dual Roles in Demyelination and Remyelination and Successful Therapeutic Intervention Using LtβR–Ig Protein

Article Information

DOI

PubMed

Published By

History

¹Lineberger Comprehensive Cancer Center,
²Neuroscience Center, and
³Department of Microbiology-Immunology, University of North Carolina, Chapel Hill, North Carolina 27599,
⁴Division of Biomedical Sciences, University of California, Riverside, California 92521, and
⁵Department of Pathology, The University of Chicago, Chicago, Illinois 60637

Correspondence should be addressed to Dr. Jenny P.-Y. Ting, Lineberger Comprehensive Cancer Center, Campus Box 7295, University of North Carolina, Chapel Hill, NC 27599. panyun{at}med.unc.edu

S. R. Plant's present address: Division of Neurology, Duke University Medical Center, Duke University, Durham, NC 27710.
H. A. Arnett's present address: Department of Inflammation, Amgen, Seattle, WA 98119.

S. R. Plant's present address: Division of Neurology, Duke University Medical Center, Duke University, Durham, NC 27710.
H. A. Arnett's present address: Department of Inflammation, Amgen, Seattle, WA 98119.

This work was supported by National Institutes of Health Grants NS34190 (J.P.-Y.T.), NS39508 (M.J.C.), NS045735 (M.J.C.), and DK58891 (Y.-X.F.) and National Multiple Sclerosis Society Grant RG1785 (J.P.-Y.T.). H.A.I. is a fellow of the National Multiple Sclerosis Society (Grant FG1605A). B.P.O. is a fellow of the Irvington Institute for Immunological Research. We thank Jeff Browning and Biogen Idec (Cambridge, MA) for generously supplying LtβR–human IgG-1 Fc, LtβR–mouse IgG-1 Fc, and matched controls human Ig and MOPC-21, as well as providing a critical review of this manuscript.
Correspondence should be addressed to Dr. Jenny P.-Y. Ting, Lineberger Comprehensive Cancer Center, Campus Box 7295, University of North Carolina, Chapel Hill, NC 27599. panyun{at}med.unc.edu

Select a custom date range for the past year