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Articles, Behavioral/Systems/Cognitive

Chronic Mild Stress during Gestation Worsens Neonatal Brain Lesions in Mice

Claire-Marie Rangon, Silvia Fortes, Vincent Lelièvre, Philippe Leroux, Frank Plaisant, Chantal Joubert, Laurence Lanfumey, Charles Cohen-Salmon and Pierre Gressens
Journal of Neuroscience 11 July 2007, 27 (28) 7532-7540; DOI: https://doi.org/10.1523/JNEUROSCI.5330-06.2007
Claire-Marie Rangon
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Silvia Fortes
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Vincent Lelièvre
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Philippe Leroux
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Frank Plaisant
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Chantal Joubert
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Laurence Lanfumey
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Charles Cohen-Salmon
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Pierre Gressens
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Abstract

Cerebral palsy remains a public health priority. Recognition of factors of susceptibility to perinatal brain lesions is key for the prevention of cerebral palsy. In most cases, the pathophysiology of these lesions is thought to involve prior exposure to predisposing factors that make the developing brain more vulnerable to perinatal events. The present study tested the hypothesis that exposure to chronic minimal stress throughout gestation would sensitize the offspring to neonatal excitotoxic brain lesions, which mimic lesions observed in cerebral palsy. Pregnant mice were exposed to chronic, ultramild stress, applied throughout gestation. Neonatal brain lesions were induced by intracerebral injection of glutamate analogs. Excitotoxic lesions were significantly worsened in pups exposed to gestational stress. Stress induced a significant rise of circulating corticosterone levels both in pregnant mothers and in newborn pups. The deleterious effects of stress on excitotoxicity were totally suppressed in mice with reduced levels of glucocorticoid receptors. Stress induced a significant increase of neopallial NMDA binding sites in the offspring. At adulthood, animals exposed to stress and neonatal excitotoxic challenge showed a significant impairment in the Morris water maze test when compared with animals exposed to the excitotoxic challenge but not the gestational stress. These findings suggest that stress during gestation, which may mimic low-level stress in human pregnancy, could be a novel risk factor for cerebral palsy.

  • cerebral palsy
  • neonatal
  • excitotoxicity
  • glucocorticoids
  • NMDA
  • sensitization
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The Journal of Neuroscience: 27 (28)
Journal of Neuroscience
Vol. 27, Issue 28
11 Jul 2007
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Chronic Mild Stress during Gestation Worsens Neonatal Brain Lesions in Mice
Claire-Marie Rangon, Silvia Fortes, Vincent Lelièvre, Philippe Leroux, Frank Plaisant, Chantal Joubert, Laurence Lanfumey, Charles Cohen-Salmon, Pierre Gressens
Journal of Neuroscience 11 July 2007, 27 (28) 7532-7540; DOI: 10.1523/JNEUROSCI.5330-06.2007

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Chronic Mild Stress during Gestation Worsens Neonatal Brain Lesions in Mice
Claire-Marie Rangon, Silvia Fortes, Vincent Lelièvre, Philippe Leroux, Frank Plaisant, Chantal Joubert, Laurence Lanfumey, Charles Cohen-Salmon, Pierre Gressens
Journal of Neuroscience 11 July 2007, 27 (28) 7532-7540; DOI: 10.1523/JNEUROSCI.5330-06.2007
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