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Articles, Cellular/Molecular

Presynaptic Ryanodine Receptor-Activated Calmodulin Kinase II Increases Vesicle Mobility and Potentiates Neuropeptide Release

Dinara Shakiryanova, Markus K. Klose, Yi Zhou, Tingting Gu, David L. Deitcher, Harold L. Atwood, Randall S. Hewes and Edwin S. Levitan
Journal of Neuroscience 18 July 2007, 27 (29) 7799-7806; DOI: https://doi.org/10.1523/JNEUROSCI.1879-07.2007
Dinara Shakiryanova
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Markus K. Klose
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Yi Zhou
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Tingting Gu
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David L. Deitcher
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Harold L. Atwood
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Randall S. Hewes
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Edwin S. Levitan
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Abstract

Although it has been postulated that vesicle mobility is increased to enhance release of transmitters and neuropeptides, the mechanism responsible for increasing vesicle motion in nerve terminals and the effect of perturbing this mobilization on synaptic plasticity are unknown. Here, green fluorescent protein-tagged dense-core vesicles (DCVs) are imaged in Drosophila motor neuron terminals, where DCV mobility is increased for minutes after seconds of activity. Ca2+-induced Ca2+ release from presynaptic endoplasmic reticulum (ER) is shown to be necessary and sufficient for sustained DCV mobilization. However, this ryanodine receptor (RyR)-mediated effect is short-lived and only initiates signaling. Calmodulin kinase II (CaMKII), which is not activated directly by external Ca2+ influx, then acts as a downstream effector of released ER Ca2+. RyR and CaMKII are essential for post-tetanic potentiation of neuropeptide secretion. Therefore, the presynaptic signaling pathway for increasing DCV mobility is identified and shown to be required for synaptic plasticity.

  • vesicle mobility
  • mobilization
  • dense-core vesicle
  • neuropeptide release
  • synaptic plasticity
  • Drosophila
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The Journal of Neuroscience: 27 (29)
Journal of Neuroscience
Vol. 27, Issue 29
18 Jul 2007
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Presynaptic Ryanodine Receptor-Activated Calmodulin Kinase II Increases Vesicle Mobility and Potentiates Neuropeptide Release
Dinara Shakiryanova, Markus K. Klose, Yi Zhou, Tingting Gu, David L. Deitcher, Harold L. Atwood, Randall S. Hewes, Edwin S. Levitan
Journal of Neuroscience 18 July 2007, 27 (29) 7799-7806; DOI: 10.1523/JNEUROSCI.1879-07.2007

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Presynaptic Ryanodine Receptor-Activated Calmodulin Kinase II Increases Vesicle Mobility and Potentiates Neuropeptide Release
Dinara Shakiryanova, Markus K. Klose, Yi Zhou, Tingting Gu, David L. Deitcher, Harold L. Atwood, Randall S. Hewes, Edwin S. Levitan
Journal of Neuroscience 18 July 2007, 27 (29) 7799-7806; DOI: 10.1523/JNEUROSCI.1879-07.2007
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