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Articles, Behavioral/Systems/Cognitive

Evidence That Long-Term Potentiation Occurs within Individual Hippocampal Synapses during Learning

Vadim Fedulov, Christopher S. Rex, Danielle A. Simmons, Linda Palmer, Christine M. Gall and Gary Lynch
Journal of Neuroscience 25 July 2007, 27 (30) 8031-8039; DOI: https://doi.org/10.1523/JNEUROSCI.2003-07.2007
Vadim Fedulov
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Christopher S. Rex
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Danielle A. Simmons
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Linda Palmer
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Christine M. Gall
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Gary Lynch
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Abstract

Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin polymerization. We used one of these, involving phosphorylation of the regulatory protein cofilin, as a marker to test whether LTP-related changes occur in hippocampal synapses during unsupervised learning. Well handled rats were allowed to explore a compartmentalized environment for 30 min after an injection of vehicle or the NMDA receptor antagonist (±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP). Another group of rats consisted of vehicle-injected, home-cage controls. Vehicle-treated rats that explored the environment had 30% more spines with dense phosphorylated (p) cofilin immunoreactivity in hippocampal field CA1 than did rats in the home-cage group. The increase in pCofilin-positive spines and behavioral evidence for memory of the explored environment were both eliminated by CPP. Coimmunostaining for pCofilin and the postsynaptic density protein 95 (PSD-95) showed that synapses on pCofilin-positive spines were substantially larger than those on neighboring (pCofilin-negative) spines. These results establish that uncommon cellular events associated with LTP, including changes in synapse size, occur in individual spines during learning, and provide a technique for mapping potential engrams.

  • cofilin
  • actin
  • PSD-95
  • phosphorylation
  • unsupervised learning
  • immunoreactivity
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The Journal of Neuroscience: 27 (30)
Journal of Neuroscience
Vol. 27, Issue 30
25 Jul 2007
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Evidence That Long-Term Potentiation Occurs within Individual Hippocampal Synapses during Learning
Vadim Fedulov, Christopher S. Rex, Danielle A. Simmons, Linda Palmer, Christine M. Gall, Gary Lynch
Journal of Neuroscience 25 July 2007, 27 (30) 8031-8039; DOI: 10.1523/JNEUROSCI.2003-07.2007

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Evidence That Long-Term Potentiation Occurs within Individual Hippocampal Synapses during Learning
Vadim Fedulov, Christopher S. Rex, Danielle A. Simmons, Linda Palmer, Christine M. Gall, Gary Lynch
Journal of Neuroscience 25 July 2007, 27 (30) 8031-8039; DOI: 10.1523/JNEUROSCI.2003-07.2007
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