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Featured ArticleFeatured ArticleArticles, Development/Plasticity/Repair

Localized Activation of p21-Activated Kinase Controls Neuronal Polarity and Morphology

Tom Jacobs, Frédéric Causeret, Yoshiaki V. Nishimura, Mami Terao, Adele Norman, Mikio Hoshino and Margareta Nikolić
Journal of Neuroscience 8 August 2007, 27 (32) 8604-8615; DOI: https://doi.org/10.1523/JNEUROSCI.0765-07.2007
Tom Jacobs
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Frédéric Causeret
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Yoshiaki V. Nishimura
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Mami Terao
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Adele Norman
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Mikio Hoshino
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Margareta Nikolić
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Abstract

In the developing forebrain, neuronal polarization is a stepwise and initially reversible process that underlies correct migration and axon specification. Many aspects of cytoskeletal changes that accompany polarization are currently molecularly undefined and thus poorly understood. Here we reveal that the p21-activated kinase (Pak1) is essential for the specification of an axon and dendrites. In hippocampal neurons, activation of Pak1 is spatially restricted to the immature axon despite its uniform presence in all neurites. Hyperactivation of Pak1 at the membrane of all neurites or loss of Pak1 expression disrupts both neuronal morphology and the distinction between an axon and dendrites. We reveal that Pak1 acts on polarity in a kinase-dependent manner, by affecting the F-actin and microtubule cytoskeleton at least in part through Rac1 and cofilin. Our data are the first to demonstrate the importance of localized Pak1 kinase activation for neuronal polarization and differentiation.

  • Pak1 kinase
  • polarity
  • neuron
  • cytoskeleton
  • F-actin
  • axon
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The Journal of Neuroscience: 27 (32)
Journal of Neuroscience
Vol. 27, Issue 32
8 Aug 2007
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Localized Activation of p21-Activated Kinase Controls Neuronal Polarity and Morphology
Tom Jacobs, Frédéric Causeret, Yoshiaki V. Nishimura, Mami Terao, Adele Norman, Mikio Hoshino, Margareta Nikolić
Journal of Neuroscience 8 August 2007, 27 (32) 8604-8615; DOI: 10.1523/JNEUROSCI.0765-07.2007

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Localized Activation of p21-Activated Kinase Controls Neuronal Polarity and Morphology
Tom Jacobs, Frédéric Causeret, Yoshiaki V. Nishimura, Mami Terao, Adele Norman, Mikio Hoshino, Margareta Nikolić
Journal of Neuroscience 8 August 2007, 27 (32) 8604-8615; DOI: 10.1523/JNEUROSCI.0765-07.2007
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