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Articles, Neurobiology of Disease

Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis

Karolina Wosik, Romain Cayrol, Aurore Dodelet-Devillers, France Berthelet, Monique Bernard, Robert Moumdjian, Alain Bouthillier, Timothy L. Reudelhuber and Alexandre Prat
Journal of Neuroscience 22 August 2007, 27 (34) 9032-9042; DOI: https://doi.org/10.1523/JNEUROSCI.2088-07.2007
Karolina Wosik
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Romain Cayrol
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Aurore Dodelet-Devillers
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France Berthelet
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Monique Bernard
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Robert Moumdjian
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Alain Bouthillier
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Timothy L. Reudelhuber
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Alexandre Prat
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2088-07.2007
PubMed 
17715340
Published By 
Society for Neuroscience
History 
  • Received February 27, 2007
  • Revision received June 1, 2007
  • Accepted July 5, 2007
  • First published August 22, 2007.
  • Version of record published August 22, 2007.
Copyright & Usage 
Copyright © 2007 Society for Neuroscience 0270-6474/07/279032-11$15.00/0

Author Information

  1. Karolina Wosik1,*,
  2. Romain Cayrol1,*,
  3. Aurore Dodelet-Devillers1,
  4. France Berthelet2,
  5. Monique Bernard1,
  6. Robert Moumdjian3,
  7. Alain Bouthillier3,
  8. Timothy L. Reudelhuber5, and
  9. Alexandre Prat1,4,6
  1. 1Neuroimmunology Research Laboratory, Center for Study of Brain Diseases,
  2. 2Department of Neuropathology,
  3. 3Department of Neurosurgery,
  4. 4Department of Neurology,
  5. 5Laboratory of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal, and
  6. 6Multiple Sclerosis Clinic, Department of Neurology, Centre Hospitalier de l'Université de Montréal-Notre Dame Hospital, University of Montreal, Montréal, Quebec, Canada H2L 4M1
  1. Correspondence should be addressed to Dr. Alexandre Prat, Multiple Sclerosis Clinic and Neuroimmunology Research Laboratory, Centre Hospitalier de l'Université de Montréal-Notre Dame Hospital, 1560 Sherbrooke Street East, Montréal, Quebec, Canada H2L 4M1. a.prat{at}umontreal.ca
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Author contributions

  1. ↵*K.W. and R.C. contributed equally to this work.

View Abstract

Disclosures

    • Received February 27, 2007.
    • Revision received June 1, 2007.
    • Accepted July 5, 2007.
  • This work was supported by grants from the Canadian Institute of Health Research (CIHR) (INO-Neuroscience Mental Health and Addiction and MOP81088), the Multiple Sclerosis Society of Canada (MSSC), and the Canadian Foundation for Innovation. A.P. holds the Donald Paty Career Development Award of the MSSC and is a Research Scholar (Junior 1) from the Fonds de Recherche en Santé du Québec. K.W. holds a fellowship from the MSSC. A.D.-D. and R.C. hold a CIHR-sponsored neuroinflammation training grant studentship. We thank Stephanie Jack for her work in setting up the MS brain bank, Dr. T. Vincent for his work with BBB-ECs/astrocyte cocultures, and Dr. Chan for the generous gift of the AT1 antagonist as well as Dr. Nathalie Arbour, Hania Kébir, and Igal Ifergan for critical reading of this manuscript.

  • Correspondence should be addressed to Dr. Alexandre Prat, Multiple Sclerosis Clinic and Neuroimmunology Research Laboratory, Centre Hospitalier de l'Université de Montréal-Notre Dame Hospital, 1560 Sherbrooke Street East, Montréal, Quebec, Canada H2L 4M1. a.prat{at}umontreal.ca

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AbstractFullPdf
Aug 200731798223
Sep 200768153129
Oct 2007459295
Nov 2007415860
Dec 2007325839
Total 2007503459546
Jan 2008416557
Feb 2008448453
Mar 2008349872
Apr 2008418066
May 2008276546
Jun 2008398957
Jul 2008547341
Aug 2008437438
Sep 2008797348
Oct 2008607763
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Total 2008537870609
Jan 2009176344
Feb 2009225331
Mar 2009325240
Apr 2009344540
May 2009193117
Jun 2009293333
Jul 2009255235
Aug 2009283736
Sep 2009473932
Oct 2009573640
Nov 2009394133
Dec 2009473142
Total 2009396513423
Jan 2010234534
Feb 2010493630
Mar 2010164230
Apr 2010333935
May 2010654431
Jun 2010353923
Jul 2010404443
Aug 20101033536
Sep 2010313332
Oct 2010333227
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Dec 2010352034
Total 2010477441394
Jan 2011243149
Feb 2011192233
Mar 2011554231
Apr 2011255241
May 2011223532
Jun 2011103335
Jul 2011194848
Aug 2011273050
Sep 2011332927
Oct 2011193330
Nov 2011403043
Dec 2011293439
Total 2011322419458
Jan 2012253540
Feb 2012202028
Mar 2012353739
Apr 2012383133
May 2012243327
Jun 2012401930
Jul 2012444237
Aug 2012354128
Sep 2012192720
Oct 2012502334
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Dec 2012372127
Total 2012413345366
Jan 2013422624
Feb 2013312415
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Apr 2013222335
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Jun 201313167
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Total 2013310252226
Jan 2014352015
Feb 2014282215
Mar 2014283027
Apr 2014191411
May 2014241816
Jun 2014261221
Jul 2014312312
Aug 2014301818
Sep 2014372521
Oct 2014362423
Nov 2014292427
Dec 2014321016
Total 2014355240222
Jan 2015202914
Feb 2015191816
Mar 201533139
Apr 2015312918
May 2015301614
Jun 2015161719
Jul 2015373122
Aug 2015242115
Sep 2015352317
Oct 2015371515
Nov 2015403015
Dec 2015312024
Total 2015353262198
Jan 2016241316
Feb 2016371317
Mar 2016282819
Apr 2016373414
May 2016302715
Jun 2016203018
Jul 2016261711
Aug 2016302321
Sep 2016961313
Oct 2016272714
Nov 20167209
Dec 2016124010
Total 2016374285177
Jan 201733054
Feb 201733210
Mar 2017114632
Apr 201762315
May 201745917
Jun 2017316611
Jul 20174715
Aug 201733415
Sep 201762012
Oct 20172296
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Dec 201732411
Total 201751578194
Jan 201823111
Feb 201862815
Mar 201893410
Apr 201863112
May 20183384
Jun 20183275
Jul 201824411
Aug 201852112
Sep 201823111
Oct 20185165
Nov 201861513
Dec 201821612
Total 201851332121
Jan 201962911
Feb 201983014
Mar 2019132617
Apr 201953426
May 201964819
Jun 201912310
Jul 201972614
Aug 2019115719
Sep 201924012
Oct 201910176
Nov 201951813
Dec 20194187
Total 201978366168
Jan 202033610
Feb 202021716
Mar 202053721
Apr 202042113
May 202074022
Jun 20204128
Jul 202053216
Aug 202063522
Sep 2020114918
Oct 202066421
Nov 202081613
Dec 2020134931
Total 202074408211
Jan 202143224
Total 202143224
Total429858024337
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The Journal of Neuroscience: 27 (34)
Journal of Neuroscience
Vol. 27, Issue 34
22 Aug 2007
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Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis
Karolina Wosik, Romain Cayrol, Aurore Dodelet-Devillers, France Berthelet, Monique Bernard, Robert Moumdjian, Alain Bouthillier, Timothy L. Reudelhuber, Alexandre Prat
Journal of Neuroscience 22 August 2007, 27 (34) 9032-9042; DOI: 10.1523/JNEUROSCI.2088-07.2007

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Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis
Karolina Wosik, Romain Cayrol, Aurore Dodelet-Devillers, France Berthelet, Monique Bernard, Robert Moumdjian, Alain Bouthillier, Timothy L. Reudelhuber, Alexandre Prat
Journal of Neuroscience 22 August 2007, 27 (34) 9032-9042; DOI: 10.1523/JNEUROSCI.2088-07.2007
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