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Articles, Neurobiology of Disease

Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic Xenopus laevis Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin

Beatrice M. Tam and Orson L. Moritz
Journal of Neuroscience 22 August 2007, 27 (34) 9043-9053; DOI: https://doi.org/10.1523/JNEUROSCI.2245-07.2007
Beatrice M. Tam
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Orson L. Moritz
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2245-07.2007
PubMed 
17715341
Published By 
Society for Neuroscience
History 
  • Received August 28, 2006
  • Revision received July 3, 2007
  • Accepted July 5, 2007
  • First published August 22, 2007.
  • Version of record published August 22, 2007.
Copyright & Usage 
Copyright © 2007 Society for Neuroscience 0270-6474/07/279043-11$15.00/0

Author Information

  1. Beatrice M. Tam and
  2. Orson L. Moritz
  1. Department of Ophthalmology and Visual Sciences, Centre for Macular Research, University of British Columbia, Vancouver, British Columbia, Canada V5Z 3N9
  1. Correspondence should be addressed to Orson L. Moritz, Department of Ophthalmology and Visual Sciences, University of British Columbia, 2550 Willow Street, Vancouver, British Columbia, Canada V5Z 3N9. olmoritz{at}interchange.ubc.ca
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Author contributions

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Disclosures

    • Received August 28, 2006.
    • Revision received July 3, 2007.
    • Accepted July 5, 2007.
  • This work was supported by the Canadian Institutes of Health Research. O.L.M. is a Michael Smith Scholar (Michael Smith Foundation for Health Research) and a W. K. Stell scholar (Foundation Fighting Blindness, Canada). We thank Dr. R. S. Molday for providing mAb 2B2, Dr. P. Hargrave for providing mAbs B630N and A5-3, Dr. D. Deretic for providing mAb 11D5, and Dr. D. Oprian for providing 11-cis retinal and the bovine rhodopsin cDNA.

  • Correspondence should be addressed to Orson L. Moritz, Department of Ophthalmology and Visual Sciences, University of British Columbia, 2550 Willow Street, Vancouver, British Columbia, Canada V5Z 3N9. olmoritz{at}interchange.ubc.ca

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AbstractFullPdf
Aug 20071606688
Sep 2007306566
Oct 2007353946
Nov 2007184731
Dec 2007242525
Total 2007267242256
Jan 2008222111
Feb 2008102713
Mar 2008113932
Apr 2008122920
May 2008112727
Jun 2008183118
Jul 2008122412
Aug 2008182910
Sep 2008253613
Oct 2008133922
Nov 2008172619
Dec 200881811
Total 2008177346208
Jan 2009183926
Feb 2009123721
Mar 2009133624
Apr 2009161515
May 2009152111
Jun 2009123319
Jul 2009112714
Aug 2009123613
Sep 200942710
Oct 200972612
Nov 2009172621
Dec 200916159
Total 2009153338195
Jan 20107147
Feb 20108186
Mar 2010141912
Apr 20108206
May 20107208
Jun 201062726
Jul 20109163
Aug 2010111111
Sep 2010102922
Oct 201072113
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Dec 20107149
Total 2010105243141
Jan 201192818
Feb 20111098
Mar 201115166
Apr 201182213
May 201162115
Jun 2011102115
Jul 2011113111
Aug 2011241220
Sep 201125615
Oct 2011162617
Nov 2011203020
Dec 201182611
Total 2011162248169
Jan 201216179
Feb 2012172220
Mar 2012251917
Apr 2012181715
May 2012262023
Jun 2012151612
Jul 2012222015
Aug 2012221214
Sep 201223914
Oct 2012111515
Nov 2012361814
Dec 201231119
Total 2012262196177
Jan 2013182116
Feb 2013271115
Mar 201334167
Apr 2013321014
May 2013182014
Jun 2013982
Jul 20131576
Aug 2013968
Sep 20131193
Oct 20131474
Nov 20132479
Dec 201320105
Total 2013231132103
Jan 201430106
Feb 201427713
Mar 20142174
Apr 20141775
May 20141974
Jun 20141792
Jul 2014211112
Aug 20141897
Sep 20141094
Oct 201416118
Nov 201412128
Dec 201410115
Total 201421811078
Jan 20151495
Feb 201515104
Mar 2015161811
Apr 20159169
May 20154184
Jun 20151075
Jul 20151868
Aug 20151666
Sep 20152378
Oct 201515107
Nov 20151363
Dec 20152376
Total 201517612076
Jan 201620165
Feb 20161839
Mar 201625616
Apr 20161751
May 20161382
Jun 201611105
Jul 20162035
Aug 201620112
Sep 201612163
Oct 20165163
Nov 20162103
Dec 201631415
Total 201616611869
Jan 20174225
Feb 20172205
Mar 201763015
Apr 201732048
May 20177354
Jun 20173196
Jul 20172185
Aug 2017480
Sep 20172165
Oct 20172255
Nov 20173146
Dec 20170152
Total 201738242106
Jan 201811813
Feb 20183711
Mar 20184166
Apr 20180157
May 20181303
Jun 20181225
Jul 20181103
Aug 20181144
Sep 20180197
Oct 20180186
Nov 20182214
Dec 20180105
Total 20181420074
Jan 20191136
Feb 20191153
Mar 201901510
Apr 20192125
May 201941510
Jun 20191168
Jul 2019298
Aug 20191189
Sep 2019094
Oct 20192123
Nov 201941811
Dec 20194127
Total 20192216484
Jan 2020274
Feb 20200127
Mar 2020272
Apr 2020255
May 2020295
Jun 20201194
Jul 20201920
Aug 2020135
Sep 202082616
Oct 20206149
Nov 202022212
Dec 202082817
Total 202035161106
Jan 20212144
Total 20212144
Total202828741846
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The Journal of Neuroscience: 27 (34)
Journal of Neuroscience
Vol. 27, Issue 34
22 Aug 2007
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Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic Xenopus laevis Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin
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Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic Xenopus laevis Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin
Beatrice M. Tam, Orson L. Moritz
Journal of Neuroscience 22 August 2007, 27 (34) 9043-9053; DOI: 10.1523/JNEUROSCI.2245-07.2007

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Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic Xenopus laevis Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin
Beatrice M. Tam, Orson L. Moritz
Journal of Neuroscience 22 August 2007, 27 (34) 9043-9053; DOI: 10.1523/JNEUROSCI.2245-07.2007
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