Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

Ángela Fontán-Lozano; José Luis Sáez-Cassanelli; Mari Carmen Inda; Mercedes de los Santos-Arteaga; Sergio Antonio Sierra-Domínguez; Guillermo López-Lluch; José María Delgado-García; Ángel Manuel Carrión

doi:10.1523/JNEUROSCI.2757-07.2007

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.2757-07.2007

PubMed

17881524

Published By

Society for Neuroscience

History

Received April 3, 2006
Revision received August 6, 2007
Accepted August 8, 2007
First published September 19, 2007.

Version of record published September 19, 2007.

Author Information

Ángela Fontán-Lozano¹,
José Luis Sáez-Cassanelli¹,
Mari Carmen Inda¹,
Mercedes de los Santos-Arteaga¹,
Sergio Antonio Sierra-Domínguez¹,
Guillermo López-Lluch²,
José María Delgado-García¹, and
Ángel Manuel Carrión¹

¹División de Neurociencias and
²Área de Biología Celular, Universidad Pablo de Olavide de Sevilla, 41013 Sevilla, Spain

Correspondence should be addressed to Dr. Ángel M. Carrión, División de Neurociencias, Universidad Pablo de Olavide, Carretera de Utrera Kilómetro 1, 41013 Sevilla, Spain. amancar{at}upo.es

M. C. Inda's present address: Instituto de Neurobiología Ramón y Cajal, Avenida Dr. Arce 37, 28002 Madrid, Spain.

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Author contributions

M. C. Inda's present address: Instituto de Neurobiología Ramón y Cajal, Avenida Dr. Arce 37, 28002 Madrid, Spain.

Disclosures

Received April 3, 2006.
Revision received August 6, 2007.
Accepted August 8, 2007.

This work was supported by grants from the Spanish Agency for International Cooperation, the Junta de Andalucía (CVI-122), CAMD2005, and the Dirección General de Investigación Ciencia y Técnica (BFU2005-01024). We thank Drs. A. Múnera and M. Sefton for critical reading and editorial assistance with this manuscript. We also thank M. C. Sutil, M. D. Marín, and M. Cadena for technical assistance with animal handling.
Correspondence should be addressed to Dr. Ángel M. Carrión, División de Neurociencias, Universidad Pablo de Olavide, Carretera de Utrera Kilómetro 1, 41013 Sevilla, Spain. amancar{at}upo.es

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	Abstract	Full	Pdf
Sep 2007	670	207	450
Oct 2007	103	125	150
Nov 2007	59	51	43
Dec 2007	27	27	39
Total 2007	859	410	682
Jan 2008	28	40	40
Feb 2008	24	29	36
Mar 2008	38	37	33
Apr 2008	39	64	63
May 2008	33	60	91
Jun 2008	37	60	65
Jul 2008	28	55	49
Aug 2008	32	57	37
Sep 2008	27	63	48
Oct 2008	62	36	27
Nov 2008	23	39	28
Dec 2008	51	36	27
Total 2008	422	576	544
Jan 2009	104	50	37
Feb 2009	26	43	41
Mar 2009	36	51	57
Apr 2009	29	34	18
May 2009	18	22	22
Jun 2009	26	20	17
Jul 2009	22	26	16
Aug 2009	22	60	14
Sep 2009	29	26	17
Oct 2009	16	19	26
Nov 2009	56	29	34
Dec 2009	43	18	18
Total 2009	427	398	317
Jan 2010	30	35	29
Feb 2010	25	28	28
Mar 2010	17	43	33
Apr 2010	27	42	26
May 2010	17	29	24
Jun 2010	9	33	15
Jul 2010	35	24	15
Aug 2010	22	26	18
Sep 2010	22	25	14
Oct 2010	30	32	21
Nov 2010	36	36	18
Dec 2010	41	38	32
Total 2010	311	391	273
Jan 2011	22	29	27
Feb 2011	18	23	17
Mar 2011	42	30	17
Apr 2011	19	14	14
May 2011	17	38	24
Jun 2011	23	12	23
Jul 2011	17	23	17
Aug 2011	18	18	22
Sep 2011	15	35	32
Oct 2011	34	31	11
Nov 2011	22	37	25
Dec 2011	22	44	27
Total 2011	269	334	256
Jan 2012	26	22	14
Feb 2012	24	22	18
Mar 2012	33	19	13
Apr 2012	47	32	21
May 2012	42	35	31
Jun 2012	52	17	24
Jul 2012	22	23	28
Aug 2012	26	23	13
Sep 2012	14	23	17
Oct 2012	23	24	22
Nov 2012	46	28	26
Dec 2012	47	17	19
Total 2012	402	285	246
Jan 2013	21	18	16
Feb 2013	24	16	20
Mar 2013	45	26	25
Apr 2013	43	25	21
May 2013	44	17	15
Jun 2013	29	20	8
Jul 2013	22	26	13
Aug 2013	16	17	12
Sep 2013	22	21	16
Oct 2013	43	17	20
Nov 2013	38	28	21
Dec 2013	30	21	10
Total 2013	377	252	197
Jan 2014	23	8	7
Feb 2014	28	16	20
Mar 2014	30	29	12
Apr 2014	35	28	14
May 2014	25	43	19
Jun 2014	19	23	16
Jul 2014	31	37	15
Aug 2014	9	15	14
Sep 2014	39	29	19
Oct 2014	19	40	12
Nov 2014	20	21	16
Dec 2014	34	25	14
Total 2014	312	314	178
Jan 2015	26	30	16
Feb 2015	27	21	13
Mar 2015	41	31	18
Apr 2015	34	35	22
May 2015	6	15	12
Jun 2015	13	14	17
Jul 2015	14	42	10
Aug 2015	10	31	3
Sep 2015	14	16	8
Oct 2015	19	14	5
Nov 2015	24	43	19
Dec 2015	14	36	9
Total 2015	242	328	152
Jan 2016	59	20	7
Feb 2016	107	13	18
Mar 2016	36	17	14
Apr 2016	14	31	9
May 2016	18	17	6
Jun 2016	17	32	9
Jul 2016	14	31	5
Aug 2016	20	26	9
Sep 2016	13	32	8
Oct 2016	14	94	12
Nov 2016	18	56	5
Dec 2016	14	55	25
Total 2016	344	424	127
Jan 2017	16	28	11
Feb 2017	109	46	14
Mar 2017	19	109	16
Apr 2017	29	70	10
May 2017	15	44	25
Jun 2017	80	37	15
Jul 2017	35	34	6
Aug 2017	40	30	4
Sep 2017	24	75	4
Oct 2017	59	59	12
Nov 2017	41	62	14
Dec 2017	19	43	5
Total 2017	486	637	136
Jan 2018	47	71	9
Feb 2018	47	51	5
Mar 2018	28	70	11
Apr 2018	25	66	10
May 2018	31	67	15
Jun 2018	27	57	13
Jul 2018	13	75	14
Aug 2018	9	62	9
Sep 2018	15	84	17
Oct 2018	35	73	16
Nov 2018	18	70	14
Dec 2018	12	59	12
Total 2018	307	805	145
Jan 2019	11	53	12
Feb 2019	18	51	18
Mar 2019	7	40	19
Apr 2019	34	82	33
May 2019	10	35	11
Jun 2019	17	41	9
Jul 2019	8	33	15
Aug 2019	15	20	21
Sep 2019	10	27	12
Oct 2019	21	30	16
Nov 2019	9	46	23
Dec 2019	14	23	12
Total 2019	174	481	201
Jan 2020	22	60	22
Feb 2020	6	21	12
Mar 2020	8	56	27
Apr 2020	15	48	28
May 2020	8	69	24
Jun 2020	6	14	8
Jul 2020	17	34	10
Aug 2020	12	14	17
Sep 2020	21	47	14
Oct 2020	13	34	8
Nov 2020	24	44	9
Dec 2020	16	34	17
Total 2020	168	475	196
Jan 2021	14	41	20
Feb 2021	19	44	12
Mar 2021	20	42	22
Apr 2021	18	31	23
May 2021	12	32	12
Jun 2021	11	40	21
Jul 2021	12	26	14
Aug 2021	3	51	19
Sep 2021	11	28	23
Oct 2021	12	41	26
Nov 2021	10	66	39
Dec 2021	34	42	9
Total 2021	176	484	240
Jan 2022	39	44	11
Feb 2022	25	57	25
Mar 2022	7	58	13
Apr 2022	37	58	15
May 2022	22	52	28
Jun 2022	5	44	5
Total 2022	135	313	97
Total	5411	6907	3987