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Brief Communications

Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation

Joseph F. Cheer, Kate M. Wassum, Leslie A. Sombers, Michael L. A. V. Heien, Jennifer L. Ariansen, Brandon J. Aragona, Paul E. M. Phillips and R. Mark Wightman
Journal of Neuroscience 24 January 2007, 27 (4) 791-795; DOI: https://doi.org/10.1523/JNEUROSCI.4152-06.2007
Joseph F. Cheer
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Kate M. Wassum
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Leslie A. Sombers
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Michael L. A. V. Heien
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Jennifer L. Ariansen
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Brandon J. Aragona
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Paul E. M. Phillips
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R. Mark Wightman
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Abstract

Transient surges of dopamine in the nucleus accumbens are associated with drug seeking. Using a voltammetric sensor with high temporal and spatial resolution, we demonstrate differences in the temporal profile of dopamine concentration transients caused by acute doses of nicotine, ethanol, and cocaine in the nucleus accumbens shell of freely moving rats. Despite differential release dynamics, all drug effects are uniformly inhibited by administration of rimonabant, a cannabinoid receptor (CB1) antagonist, suggesting that an increase in endocannabinoid tone facilitates the effects of commonly abused drugs on subsecond dopamine release. These time-resolved chemical measurements provide unique insight into the neurobiological effectiveness of rimonabant in treating addictive disorders.

  • rimonabant
  • dopamine
  • cocaine
  • nicotine
  • ethanol
  • cyclic voltammetry
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The Journal of Neuroscience: 27 (4)
Journal of Neuroscience
Vol. 27, Issue 4
24 Jan 2007
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Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
Joseph F. Cheer, Kate M. Wassum, Leslie A. Sombers, Michael L. A. V. Heien, Jennifer L. Ariansen, Brandon J. Aragona, Paul E. M. Phillips, R. Mark Wightman
Journal of Neuroscience 24 January 2007, 27 (4) 791-795; DOI: 10.1523/JNEUROSCI.4152-06.2007

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Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
Joseph F. Cheer, Kate M. Wassum, Leslie A. Sombers, Michael L. A. V. Heien, Jennifer L. Ariansen, Brandon J. Aragona, Paul E. M. Phillips, R. Mark Wightman
Journal of Neuroscience 24 January 2007, 27 (4) 791-795; DOI: 10.1523/JNEUROSCI.4152-06.2007
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