Article Information
- Received July 26, 2006
- Revision received December 9, 2006
- Accepted December 18, 2006
- First published January 24, 2007.
- Version of record published January 24, 2007.
Author Information
- Michael Koenigs and
- Daniel Tranel
- Department of Neurology, Division of Cognitive Neuroscience, University of Iowa College of Medicine and Neuroscience Graduate Program, University of Iowa, Iowa City, Iowa 52242
- Correspondence should be addressed to Dr. Michael Koenigs, Building 10, Room 7-5648, 10 Center Drive, Bethesda, MD 20892. koenigsm{at}ninds.nih.gov
Author contributions
Disclosures
- Received July 26, 2006.
- Revision received December 9, 2006.
- Accepted December 18, 2006.
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This work was supported by National Institute of Neurological Disorders and Stroke Grant P01 NS19632 and National Institute on Drug Abuse Grant R01 DA022549. We thank Hanna Damasio for making available her neuroanatomical analyses of VMPC patients and for preparing Figure 1.
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↵a Because the offer screen was presented for a fixed 4 s before the “Accept or Reject?” screen appeared, and some subjects would attempt to make their response before the appearance of that screen whereas others would wait, response times for the “Accept or Reject?” screen were not meaningful, and thus response times are not reported.
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↵b For example, one of the target patients (patient 2) is accompanied to her hospital visits by her nearly 90-year-old mother. In a recent visit to our neurology clinic, the mother was slow to find that patient's appointment slip during their arrival. Patient 2 reacted by screaming violently at her mother in the patient waiting area. Other patients have similar tantrum-like responses to relatively minor provocation. Examples of triggers for similar outbursts of anger include political disagreements with friends (Patient 3), a spouse's suggestion to use headlights while driving (Patient 1), and a mother's recommendation to change a clothing combination (Patient 4). The key feature of the target patients' angry responses towards others is that they are not commensurate with the provocation.
- Correspondence should be addressed to Dr. Michael Koenigs, Building 10, Room 7-5648, 10 Center Drive, Bethesda, MD 20892. koenigsm{at}ninds.nih.gov