Figure 2.
Motor performance of WT, HET, and KO mice.
A
,
B
, Evaluation of motor coordination for P14 mice using a modified footprint test (see Materials and Methods).
A
, Top, Digital pictures illustrating consecutive footsteps of representative NaV1.1 WT, HET, and KO mice. Bottom, Histograms showing the variability in stride length for each of these exemplar mice.
B
, Summary stride length and stride length variability of NaV1.1 WT, HET, and KO mice (CV, coefficient of variation).
C
,
D
, Evaluation of motor reflex using the tail suspension test.
C
, Example pictures of mice performing the reaching test.
D
, Summary data showing the time spent reaching for the cage bars for NaV1.1 WT, HET, and KO mice.
E
, Evaluation of motor coordination for P21 mice in a modified footprint test. Top, Representative digital pictures with marks showing placements of paws (gray circles for hindpaws; black for forepaws) as mice walked through the tunnel. Scale bars, 2 cm. Bottom, Summary of distance between ipsilateral forepaw and hindpaw position (FP–HP), stride length, and stride width for HET mice normalized versus WT mice. Error bars indicate SEM. *p < 0.02.