Figure 1.
Antidepressant-like activity of WIN in the rat FST. A, Behavioral effects of intraperitoneally administered vehicle, CIT (5 mg/kg, i.p.), DMI (10 mg/kg, i.p.), and WIN (0.05, 0.1, 0.2, 1.0, and 2.0 mg/kg, i.p.). Single injection of RIM (1 mg/kg, i.p.) 10 min before administration of a low dose of WIN (0.2 mg/kg, i.p.) blocked the antidepressant-like effect. Single injection of RIM (1 mg/kg, i.p.) 10 min before administration of a high dose of WIN (2 mg/kg, i.p.) did not modify the inert effect of WIN. Note that RIM by itself did not have any significant effect. B, The antidepressant-like effect of WIN (0.2 mg/kg, i.p.) was abrogated by pretreatment with pCPA (150 mg/kg, i.p.) 72 and 48 h before pretest. Pretreatment of pCPA by itself did not have any significant effect. All treatments were administered 23, 5, and 0.75 h before test swim according to the method of Page et al. (1999). n = 8–15 per treatment group. Bars represent mean ± SEM total time of behaviors indicated. *p < 0.05 or **p < 0.01 versus vehicle.
