Figure 7.
Figure 7.
Behavioral effects of bilateral microinfusion of WIN and RIM into the mPFCv in the rat FST. WIN (1 or 5 μg in 0.5 μl of vehicle infused for 3 min) administered 7–10 min before the FST increased total time spent swimming and decreased total time spent immobile. Bilateral microinfusion of RIM (1 μg in 0.25 μl of vehicle for 1.5 min) 1 min before microinfusion of WIN (1 μg in 0.25 μl for 1.5 min) abrogated antidepressant-like effect. RIM (1 μg in 0.5 μl of vehicle for 3 min) did not have any significant effect. n = 7–11 animals per treatment group. **p < 0.01 versus vehicle.
