Article Figures & Data
Figures
- Figure 1.
The event-related numerical WM task paradigm.
- Figure 2.
Regions activated in the contrasts of interest (left), corresponding ROIs with COMT Val>Met effects (middle), and extracted signal from the prefrontal ROI according to COMT genotype (right).
- Figure 3.
Relative to baseline numerical size judgment, extracted parameter estimates from the working memory manipulation task (E_CJ > J) and numerical manipulation task (CJ > J) showed a task-by-genotype interaction at the DLPFC.
Tables
VV SD VM SD MM SD F p (n = 8) (n = 8) (n = 6) Age 28.17 7.11 33.38 7.09 27.00 9.62 1.78 0.19 Gender (number of males) 4 5 4 χ2 = 0.45 0.80 Education 16.17 2.71 16.75 2.60 16.80 3.27 0.09 0.91 WAIS IQ 101.0 13.6 109.4 14.1 103.8 7.2 0.81 0.46 Accuracy Numerical size judgement (J) 0.908 0.074 0.900 0.104 0.930 0.027 0.37 0.69 Numerical computation and J (CJ) 0.867 0.113 0.756 0.247 0.850 0.141 1.05 0.37 Retrieval and J (E_RJ) 0.933 0.061 0.969 0.053 0.920 0.076 0.12 0.89 Numerical computation in working memory and J (E_CJ) 0.733 0.061 0.700 0.235 0.770 0.110 0.35 0.71 Motor task (M) 0.992 0.020 0.969 0.059 0.980 0.045 0.28 0.76 Reaction time (s) Numerical size judgement (J) 1.388 0.289 1.407 0.263 1.318 0.148 0.65 0.53 Numerical computation and J (CJ) 1.983 0.256 1.795 0.376 1.908 0.113 0.73 0.49 Retrieval and J (E_RJ) 1.152 0.191 1.091 0.204 1.130 0.156 0.29 0.75 Numerical computation in working memory and J (E_CJ) 1.804 0.256 1.849 0.204 2.041 0.229 0.24 0.79 Motor task (M) 0.918 0.206 0.918 0.110 0.911 0.117 0.17 0.85 -
There were no significant demographic or performance differences across COMT genotype groups. VV, Val-homozygote; VM, Val-Met hetrozygote; MM, Met-homozygote.
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Supplemental Data
Files in this Data Supplement:
- supplemental material - Supplemental Tables
- supplemental material - Supplemental Figure 1
- supplemental material - Supplemental Figure 2
- supplemental material - Supplemental Figure 3
Catechol-O-Methyltransferase Val158Met Modulation of Prefrontal–Parietal–Striatal Brain Systems during Arithmetic and Temporal Transformations in Working Memory
