Article Figures & Data
Figures
- Figure 1.
Disentangling the task-activation ensemble with task-free fcMRI. A, A spatial working memory activation map (two-back minus control) was used to select seed ROIs (circled) within the right frontal lobe. B, Temporal correlations in BOLD signal determined the intrinsic connectivity patterns with the frontoinsular (red-orange colorbar) and dorsolateral prefrontal (blue-green colorbar) ROIs (height and extent thresholds, p < 0.001, corrected) during undirected wakefulness. For display purposes, the t-score color bars in B were adjusted so that the top of the bar reflects the maximum t score seen outside the seed ROI for each network. Effortful tasks like the one used in A often coactivate the networks disentangled using a task-free, intrinsic connectivity analysis in B. These ROI-based maps (B) were used as templates for subsequent independent components analyses (Fig. 2). Functional images are displayed on a standard brain template (MNI). On axial and coronal images, the left side of the image corresponds to the left side of the brain.
- Figure 2.
Separable intrinsic connectivity networks revealed by independent component analysis. The salience network (red-orange colorbar) is anchored by paralimbic anterior cingulate and frontoinsular cortices and features extensive connectivity with subcortical and limbic structures. In the executive-control network (blue-green colorbar), the dorsolateral frontal and parietal neocortices are linked, with more selective subcortical coupling. Functional images are displayed as in Figure 1. AI, Anterior insula; antTHAL, anterior thalamus; dCN, dorsal caudate nucleus; dmTHAL, dorsomedial thalamus; DMPFC, dorsomedial prefrontal cortex; HT, hypothalamus; PAG, periaqueductal gray; Put, putamen; SLEA, sublenticular extended amygdala; SN/VTA, substantia nigra/ventral tegmental area; TP, temporal pole; VLPFC, ventrolateral prefrontal cortex.
- Figure 3.
Dissociable correlations between intrinsic functional connectivity and individual differences in emotion and cognition. Within the salience network, functional connectivity in two clusters, the dACC, and dorsolateral prefrontal cortex (−32, 44, 16, BA 46 data not shown) correlate with subject ratings of prescan anxiety (left). Within the executive-control network, functional connectivity in two clusters, located in the bilateral intraparietal sulcus/superior parietal lobule, predicts superior Trails B performance (right). Scatterplots depict these correlations graphically in the larger of the two significant clusters from each map. The y-axes show averaged voxel z-scores within the dACC or right intraparietal sulcus (IPS) cluster from each subject's salience or executive-control component, respectively. The z-scores here reflect the degree to which the time series of a given region is correlated with the overall network time series. Note that the correlation between prescan anxiety and dACC z-scores was recalculated with the outlying data point (anxiety rating of 7) removed and the correlation remained significant with an r2 value of 0.74 (p < 0.0001 for Fisher's r to z). Functional images are displayed as in Figure 1..
Additional Files
Supplemental Data
Files in this Data Supplement:
- supplemental material - Supplemental legends and tables
- supplemental material - Figure 1
- supplemental material - Figure 2
- supplemental material - Figure 3
- supplemental material - Figure 4
