Figure 2.
Temporal and spatial RGC receptive field maps of representative recordings from wild-type (A, B), Vsx1+/−Irx5+/− (C, D) and dko (E, F) mice. RGC light responses were recorded in mice aged P80–P100. A, C, E, Temporal structure of receptive field centers of RGCs recorded from a single patch of wild-type (A, 15 RGCs), Vsx1+/−Irx5+/− (C, 18 RGCs), or dko (E, 13 RGCs) retina are shown. Spike-triggered average waveforms in these plots were normalized to their amplitude and color coded to indicate fast ON (magenta), medium ON (green), biphasic OFF (blue), and monophasic OFF (red) RGCs. B, D, F, Spatial distribution of RGC receptive fields from the same recordings as in A, C, E, respectively, is depicted by plotting the 1-SD contours of two-dimensional Gaussian fits to receptive field profiles. Receptive field contours are color coded as indicated, and plots of the different cell types are offset for visual clarity. Dots represent a common point on the multielectrode array.