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Featured ArticleArticles, Neurobiology of Disease

Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus

Anikó Ludányi, Loránd Erőss, Sándor Czirják, János Vajda, Péter Halász, Masahiko Watanabe, Miklós Palkovits, Zsófia Maglóczky, Tamás F. Freund and István Katona
Journal of Neuroscience 19 March 2008, 28 (12) 2976-2990; DOI: https://doi.org/10.1523/JNEUROSCI.4465-07.2008
Anikó Ludányi
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Loránd Erőss
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Sándor Czirják
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János Vajda
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Péter Halász
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Masahiko Watanabe
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Miklós Palkovits
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Zsófia Maglóczky
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Tamás F. Freund
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István Katona
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4465-07.2008
PubMed 
18354002
Published By 
Society for Neuroscience
History 
  • Received September 29, 2007
  • Revision received January 21, 2008
  • Accepted February 7, 2008
  • First published March 19, 2008.
  • Version of record published March 19, 2008.
Copyright & Usage 
Copyright © 2008 Society for Neuroscience 0270-6474/08/282976-15$15.00/0

Author Information

  1. Anikó Ludányi 1 ,
  2. Loránd Erőss 2 ,
  3. Sándor Czirják 2 ,
  4. János Vajda 2 ,
  5. Péter Halász 3 ,
  6. Masahiko Watanabe 4 ,
  7. Miklós Palkovits 5 ,
  8. Zsófia Maglóczky 1 ,
  9. Tamás F. Freund 1 , and
  10. István Katona 1
  1. 1Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary,
  2. 2National Institute of Neurosurgery, H-1145 Budapest, Hungary,
  3. 3National Institute of Psychiatry and Neurology, Epilepsy Center, H-1021 Budapest, Hungary,
  4. 4Department of Anatomy, Hokkaido University School of Medicine, 060-8638 Sapporo, Japan, and
  5. 5Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Semmelweis University and Hungarian Academy of Sciences, H-1094 Budapest, Hungary
  1. Correspondence should be addressed to Dr. István Katona, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary. katona{at}koki.hu
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Author contributions

Disclosures

    • Received September 29, 2007.
    • Revision received January 21, 2008.
    • Accepted February 7, 2008.
  • This work was supported by Országos Tudományos Kutatási Alapprogramok (OTKA) Grants T046820 (T.F.F.) and F046407 (I.K.), Egészségügyi Tudományos Tanács Grant 561/2006 (I.K.), Nemzeti Kutatási és Fejlesztési Program Grant 1A/002/2004 (T.F.F.), by the Szentágothai János Knowledge Center (RET 5/2004), and by National Institutes of Health Grant MH54671 (T.F.F.). I.K. is a grantee of the János Bolyai scholarship. We are grateful to Sándor Koncz and Izinta Kft for their help with real-time PCR experiments and to Prof. Péter Sótonyi and Dr. Zsolt Borostyánkői (Semmelweis University, Budapest, Hungary) for providing control human tissue. We also thank for Katalin Lengyel, Katalin Iványi, Emőke Simon, Gabriella Urbán, and Győző Goda for excellent technical assistance; Ken Mackie, Barna Dudok, and Rita Nyilas for comments on this manuscript; Kinga Tóth for her help in cell counting; and Dr. Gábor Nyíri for help with the statistical analysis.

  • Correspondence should be addressed to Dr. István Katona, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary. katona{at}koki.hu

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The Journal of Neuroscience: 28 (12)
Journal of Neuroscience
Vol. 28, Issue 12
19 Mar 2008
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Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus
Anikó Ludányi, Loránd Erőss, Sándor Czirják, János Vajda, Péter Halász, Masahiko Watanabe, Miklós Palkovits, Zsófia Maglóczky, Tamás F. Freund, István Katona
Journal of Neuroscience 19 March 2008, 28 (12) 2976-2990; DOI: 10.1523/JNEUROSCI.4465-07.2008

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Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus
Anikó Ludányi, Loránd Erőss, Sándor Czirják, János Vajda, Péter Halász, Masahiko Watanabe, Miklós Palkovits, Zsófia Maglóczky, Tamás F. Freund, István Katona
Journal of Neuroscience 19 March 2008, 28 (12) 2976-2990; DOI: 10.1523/JNEUROSCI.4465-07.2008
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