Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury

Vicki M. Tysseling-Mattiace; Vibhu Sahni; Krista L. Niece; Derin Birch; Catherine Czeisler; Michael G. Fehlings; Samuel I. Stupp; John A. Kessler

doi:10.1523/JNEUROSCI.0143-08.2008

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.0143-08.2008

PubMed

18385339

Published By

Society for Neuroscience

History

Received November 1, 2007
Revision received March 5, 2008
Accepted March 7, 2008
First published April 2, 2008.

Version of record published April 2, 2008.

Author Information

Vicki M. Tysseling-Mattiace¹,*,
Vibhu Sahni¹,*,
Krista L. Niece³,
Derin Birch¹,
Catherine Czeisler¹,
Michael G. Fehlings⁴,
Samuel I. Stupp²,³, and
John A. Kessler¹

¹Department of Neurology and
²Department of Medicine and Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois 60611,
³Departments of Materials Science and Engineering and Chemistry, Northwestern University, Evanston, Illinois 60208, and
⁴Department of Surgery, University of Toronto, Toronto, Ontario, Canada M5S 1A8

Correspondence should be addressed to Vicki M. Tysseling-Mattiace, 303 E. Chicago Avenue, Chicago, IL 60611. v-mattiace{at}northwestern.edu

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Author contributions

↵*V.M.T.-M. and V.S. contributed equally to this work.

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Disclosures

Received November 1, 2007.
Revision received March 5, 2008.
Accepted March 7, 2008.

This project was supported by National Institutes of Health Grants R01 EB003806-01 (S.I.S., J.A.K.), R01 NS20013-21 (J.A.K.), and P50 NS54287 (J.A.K.) and by a scholarship from the Foundation for Physical Therapy (V.M.T.). We thank Bridgid Nolan, Tammy McGuire, and Min Hu for assistance with animal care, Hongzhou Jiang for help with the scanning electron microscopy, and Jie Huang for help with statistics. We thank Oswald Steward and his laboratory for advice and training on the tract-tracing methodology.
S.S. has founded a company, Nanotope, to eventually develop commercial applications of the self-assembling materials. S.I.S. and J.A.K. participate in this venture.
Correspondence should be addressed to Vicki M. Tysseling-Mattiace, 303 E. Chicago Avenue, Chicago, IL 60611. v-mattiace{at}northwestern.edu

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	Abstract	Full	Pdf
Apr 2008	937	391	760
May 2008	180	198	189
Jun 2008	236	136	206
Jul 2008	188	74	126
Aug 2008	108	68	74
Sep 2008	204	88	96
Oct 2008	115	202	160
Nov 2008	100	183	147
Dec 2008	57	156	127
Total 2008	2125	1496	1885
Jan 2009	61	98	108
Feb 2009	81	151	106
Mar 2009	112	197	169
Apr 2009	88	118	132
May 2009	56	121	99
Jun 2009	45	117	120
Jul 2009	48	111	81
Aug 2009	31	72	76
Sep 2009	49	81	75
Oct 2009	61	98	131
Nov 2009	78	92	90
Dec 2009	83	70	85
Total 2009	793	1326	1272
Jan 2010	70	75	65
Feb 2010	99	77	79
Mar 2010	91	74	87
Apr 2010	67	80	73
May 2010	69	63	71
Jun 2010	54	52	48
Jul 2010	37	31	44
Aug 2010	63	43	72
Sep 2010	55	37	54
Oct 2010	68	51	67
Nov 2010	81	83	95
Dec 2010	64	32	43
Total 2010	818	698	798
Jan 2011	59	51	74
Feb 2011	50	57	79
Mar 2011	100	52	70
Apr 2011	90	51	66
May 2011	74	50	63
Jun 2011	69	35	47
Jul 2011	73	40	59
Aug 2011	74	26	61
Sep 2011	78	36	57
Oct 2011	89	50	86
Nov 2011	98	60	101
Dec 2011	63	54	62
Total 2011	917	562	825
Jan 2012	67	33	61
Feb 2012	85	43	104
Mar 2012	101	55	89
Apr 2012	85	47	72
May 2012	98	42	72
Jun 2012	67	40	41
Jul 2012	66	26	51
Aug 2012	58	25	45
Sep 2012	58	36	64
Oct 2012	82	27	50
Nov 2012	97	20	47
Dec 2012	100	39	53
Total 2012	964	433	749
Jan 2013	82	35	47
Feb 2013	97	43	55
Mar 2013	120	34	59
Apr 2013	119	54	46
May 2013	120	37	52
Jun 2013	56	32	89
Jul 2013	65	27	177
Aug 2013	72	26	242
Sep 2013	71	32	228
Oct 2013	94	34	55
Nov 2013	100	43	43
Dec 2013	76	29	40
Total 2013	1072	426	1133
Jan 2014	97	33	58
Feb 2014	98	27	59
Mar 2014	99	22	62
Apr 2014	95	26	51
May 2014	95	36	53
Jun 2014	115	24	33
Jul 2014	131	36	35
Aug 2014	55	16	27
Sep 2014	119	21	37
Oct 2014	88	44	35
Nov 2014	81	31	44
Dec 2014	65	17	28
Total 2014	1138	333	522
Jan 2015	86	38	38
Feb 2015	76	18	53
Mar 2015	137	26	50
Apr 2015	129	30	50
May 2015	116	28	51
Jun 2015	66	35	38
Jul 2015	64	33	27
Aug 2015	73	31	30
Sep 2015	78	28	40
Oct 2015	96	27	42
Nov 2015	89	46	57
Dec 2015	64	35	19
Total 2015	1074	375	495
Jan 2016	99	27	48
Feb 2016	78	42	42
Mar 2016	65	45	35
Apr 2016	85	53	49
May 2016	62	44	37
Jun 2016	56	18	21
Jul 2016	62	23	34
Aug 2016	57	14	20
Sep 2016	58	16	63
Oct 2016	113	50	50
Nov 2016	43	53	68
Dec 2016	30	54	33
Total 2016	808	439	500
Jan 2017	40	79	45
Feb 2017	35	77	41
Mar 2017	44	102	33
Apr 2017	47	85	98
May 2017	34	80	50
Jun 2017	16	64	29
Jul 2017	23	54	22
Aug 2017	20	49	13
Sep 2017	34	61	34
Oct 2017	47	56	40
Nov 2017	31	75	42
Dec 2017	18	55	18
Total 2017	389	837	465
Jan 2018	39	65	32
Feb 2018	15	36	16
Mar 2018	29	58	26
Apr 2018	40	191	33
May 2018	29	97	30
Jun 2018	26	58	30
Jul 2018	22	72	29
Aug 2018	12	49	18
Sep 2018	24	63	27
Oct 2018	32	77	56
Nov 2018	32	55	55
Dec 2018	17	60	28
Total 2018	317	881	380
Jan 2019	24	36	21
Feb 2019	30	34	22
Mar 2019	57	52	38
Apr 2019	37	52	41
May 2019	49	39	23
Jun 2019	22	45	28
Jul 2019	19	46	27
Aug 2019	21	31	23
Sep 2019	23	18	14
Oct 2019	16	36	15
Nov 2019	18	52	29
Dec 2019	9	39	13
Total 2019	325	480	294
Jan 2020	21	27	15
Feb 2020	14	21	17
Mar 2020	13	41	22
Apr 2020	17	51	29
May 2020	14	78	36
Jun 2020	18	32	23
Jul 2020	15	28	28
Aug 2020	23	26	46
Sep 2020	29	45	52
Oct 2020	20	51	28
Nov 2020	26	42	26
Dec 2020	22	48	19
Total 2020	232	490	341
Jan 2021	12	49	30
Feb 2021	18	38	18
Mar 2021	29	50	47
Apr 2021	20	42	33
May 2021	21	55	26
Jun 2021	14	42	23
Jul 2021	26	50	44
Aug 2021	23	38	16
Sep 2021	13	44	29
Oct 2021	18	55	44
Nov 2021	87	132	125
Dec 2021	46	142	58
Total 2021	327	737	493
Jan 2022	18	36	17
Total 2022	18	36	17
Total	11317	9549	10169