Cover legend: Confocal image of the leading processes extended by migratory neurons within the developing enteric nervous system of Manduca sexta. The neurons and their processes (yellow) coexpress the GPI-linked ephrin ligand MsEphrin (red) and the homophilic adhesion receptor fasciclin II (green). The neurons travel selectively along visceral muscle bands on the gut that also express fasciclin II (green) while avoiding the adjacent midline muscles expressing the Eph receptor MsEph (blue). Manipulations that interfere with endogenous MsEphrin–MsEph interactions in cultured embryos cause the neurons to cross the midline inappropriately. The image was acquired at the Live Cell Imaging Facility in the Center for Research on Occupational and Environmental Toxicology at Oregon Health & Science University with the assistance of Dr. Stefanie Kaech-Petri. For more information, see the article by Coate et al. in this issue (pages 3846–3860).