Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors

This work was supported in part by a Clinical and Translational Science Award, National Center for Research Resources (NCRR) Grant UL1 RR0249139 [a component of the National Institutes of Health (NIH)], NIH Grant P01 NS 047300 (R.H.L., PI), and an agreement between Massachusetts General Hospital and Shiseido (Tokyo, Japan). Psychophysical experiments were approved by the Yale University Human Investigation Committee. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. We thank Jessica Zvara, Kristine Kenning, Parul Sikand, Barry Green, and Kounga Kounga for their input and technical assistance.